Larygotracheitis Virus (LT) Vector Vaccines for use with Avian Respiratory Pathogens

Abstract

The present invention provides compositions and methods for immunizing a subject in need thereof again an avian pathogen. In one aspect, the invention provides a composition for immunizing an avian subject against a pathogen comprising: a) a recombinant laryngotracheitis virus vector (rLT); and b) a fusion gene of an avian virus (F) inserted into the recombinant laryngotracheitis virus vector (rLT/F); wherein the recombinant laryngotracheitis virus vector inserted with the fusion gene of the avian virus (rLT/F) is deoptimized to generate deoptimized rLT/F vaccine candidates; and wherein the deoptimized rLT/F vaccine candidates are administered to the subject in need thereof.

Dependencies are inferred from the claim text.