Inhibitors of Molluscum Contagiosum Infection and Methods Using the Same

A compound of formula (I), or a salt, solvate, enantiomer, diastereoisomer, geometric isomer, or tautomer thereof:

• wherein:
• X is CR1 or N;
• Y is CR2 or N;
• optionally wherein one of the following applies:
• X is CR1 and Y is CR2;
• X is N and Y is N;
• X is CR1 and Y is N;
• X is N and Y is CR2
• R1 is H, optionally substituted C1-C6 alkyl, —C(═O)NR6R6, —C(═O)OR6, or R8;
• R2 is H or optionally substituted C1-C6 alkyl;
• R3 is H, —CN, —C(═O)OR6, —C(═O)NR6R6, optionally substituted phenyl, or optionally substituted C1-C6 alkyl;
• R4 is —C(═O)OR6 or R8;
• each occurrence of R5 is independently optionally substituted C1-C6 alkyl or optionally substituted phenyl;
• each occurrence of R6 is independently H or optionally substituted C1-C6 alkyl,
• or two R6 combine with the N atom to which both are bound to form optionally substituted 4-7 membered heterocyclyl;
• R8 is —C(═O)NH (optionally substituted acyl), —N (optionally substituted acyl)C(═O)R7, —NR6C(═O)R7 or —NR6C(═O)NR6R7;
• each occurrence of R7 is independently optionally substituted C1-C6 alkyl, optionally substituted cycloalkyl, CH (optionally substituted heterocyclyl)(R5), CH(R5)(R5), or optionally substituted 4-7 membered heterocyclyl,
• or R6 and R7 combine with the N atom to which both are bound to form optionally substituted 4-7 membered heterocyclyl;
• with the proviso that (I) comprises a single R8;
• and
• with the proviso that the compound is not selected from the group consisting of Compounds 1, 2, 4, 5, 8, 9, 15, 16, 17, 19, 24, 26, 29, 31, 40, 66, 72, 76, 77, 78, 83, 84, and 86.