Subject-specific image-based multimodal automatic 3d pre-surgical and real-time guidance system for neural intervention

A system for reconstruction of at least one target brain structure, comprising:

• at least one processor executing a code for processing a plurality of images depicting a brain of a subject by:
• reconstructing at least a part of the brain comprising boundaries of a plurality of brain structures that include the at least one target brain structure, wherein the reconstruction is insufficient for parceling of the at least one target brain structure into sub-structures of a same type of gray or white matter;
• reconstructing and parceling the at least one target brain structure using a reference atlas;
• segmenting and parceling at least one originating brain structure using the reference atlas;
• filtering white matter fibers to isolate at least one target white matter tract connecting the at least one originating brain structure and the at least one target brain structure;
• and
• creating a 3D reconstruction of the at least one target brain structure and the at least one target white matter tract, wherein the at least one target white matter tract and the at least one target brain structure are defined within an anatomical native space.

A non-transitory medium storing program instructions for reconstruction of at least one target brain structure, which, when executed by at least one processor, cause the at least one processor to:

• process a plurality of images depicting a brain of a subject by:
• reconstructing at least a part of the brain comprising boundaries of a plurality of brain structures that include the at least one target brain structure, wherein the reconstruction is insufficient for parceling of the at least one target brain structure into sub-structures of a same type of gray or white matter;
• reconstructing and parceling the at least one target brain structure using a reference atlas;
• segmenting and parceling at least one originating brain structure using the reference atlas;
• filtering white matter fibers to isolate at least one target white matter tract connecting the at least one originating brain structure and the at least one target brain structure;
• and
• creating a 3D reconstruction of the at least one target brain structure and the at least one target white matter tract, wherein the at least one target white matter tract and the at least one target brain structure are defined within an anatomical native space.