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US 2025/0282901 A1Published application
Polymeric chelators cross-linked with high molecular weight cross-linkers
AssigneeUniversity of Kansas
InventorsCory BERKLAND, Jian QIAN
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Abstract
Compositions comprising a polymeric chelator comprising a plurality of polyamine polymer backbone chains and one or more chelators covalently coupled thereto, wherein the plurality of polyamine polymer backbone chains are cross-linked with a plurality of cross-linkers each having a number average molecular weight of 200 Daltons to 6000 Daltons. Also disclosed are methods of making and using the composition, e.g., for removing metal from a medium or treating iron overload disease.
Claims47
A composition comprising:
- a polymeric chelator comprising a plurality of polyamine polymer backbone chains and one or more chelators;
- wherein the one or more chelators are covalently coupled to one or more primary and/or secondary amines of at least one of the plurality of polyamine polymer backbone chains;
- wherein the plurality of polyamine polymer backbone chains are cross-linked with a plurality of cross-linkers;
- and
- and wherein the plurality of cross-linkers each have a number average molecular weight of 200 Daltons to 6000 Daltons.
2 more elements
A method of preparing a polymeric chelator, the method comprising:
- cross-linking a plurality of polyamine polymers with a plurality of cross-linkers to form a plurality of polyamine polymer backbone chains that are cross-linked;
- and
- coupling one or more chelators to one or more primary and/or secondary amines of at least one of the plurality of polyamine polymer backbone chains,
- wherein the plurality of cross-linkers each have a number average molecular weight of 200 Daltons to 6000 Daltons.
1 more element
Dependencies are inferred from the claim text.