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US 2025/0281584 A1Published application
Active vaccination for the treatment of ngf-related disorders
AssigneeBoehringer Ingelheim Vetmedica GmbH
InventorsLaurent Bernard FISCHER, Andreas GALLEI
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Abstract
The present invention relates to veterinary compositions comprising NGF antigen linked to modified virus-like particles (VLPs) of Cucumber Mosaic Virus (CMV), in particular to modified VLPs of CMV comprising chimeric CMV polypeptides for use in a method of treating a NGF-related disorder in canine, in particular in the treatment of pain, such as for example pain associated with osteoarthritis (OA) in dogs
Claims29
A method of treating a NGF-related disorder in canine comprising the administration of a composition to said canine, wherein the composition comprises
- (a) a virus-like particle (VLP) of Cucumber Mosaic Virus (CMV), wherein said CMV VLP comprises at least one first attachment site;
- and
- (b) at least one antigen, wherein said antigen comprises at least one second attachment site, and wherein said antigen is a nerve growth factor (NGF) antigen;
- and
- wherein (a) and (b) are linked through said at least one first and said at least one second attachment site.
2 more elements
Dependencies are inferred from the claim text.