Nicotine formulations
AssigneeEmplicure AB (publ)
InventorsHåkan ENGQVIST, Jesper LÖÖF
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Abstract
There is provided a powder comprising a solid, porous chemically bonded ceramic system and nicotine or a salt thereof, wherein the nicotine or salt thereof is located within pores of the chemically bonded ceramic system. An intraoral formulation containing the powder may be held in the mouth where it releases the nicotine and contributes to providing an environment that facilitates nicotine uptake into the blood stream.
Claims34
A powder comprising a solid, porous chemically bonded ceramic system and nicotine or a salt thereof, wherein the nicotine or salt thereof is located within pores of the chemically bonded ceramic system.
The powder according to any one of the preceding claims, wherein the powder is prepared using a salt of nicotine.
The powder according to any one of the preceding claims, wherein the powder gives a pH of at least 8 upon contact with saliva.
The powder according to any one of the preceding claims, wherein the chemically bonded ceramic system is based on a calcium phosphate, a calcium sulphate, a calcium silicate, a calcium aluminate, or a mixture thereof.
The powder according to any one of the preceding claims, wherein the chemically bonded ceramic system is based on a calcium sulphate.
The powder according to any one of the preceding claims, wherein the chemically bonded ceramic system is present at from about 40% to about 98% by weight of the powder.
The powder according to any one of the preceding claims, wherein the powder further comprises a substance that is either liquid under ambient conditions or is a low-melting solid.
The powder according to any one of the preceding claims, wherein the powder further comprises a pH regulating agent.
The powder according to any one of the preceding claims, wherein the powder is provided in the form of particles or granules.
The powder according to any one of the preceding claims, wherein the powder further contains a filler, a flavour, a sialogogue and/or a controlled release agent.
The powder according to any one of the preceding claims, wherein the powder is suitable for use in a pouch for releasing nicotine or a salt thereof when said pouch is placed in the mouth.
A powder comprising a solid, porous chemically bonded ceramic system and a flavour, wherein the flavour is located within pores of the chemically bonded ceramic system.
Dependencies are inferred from the claim text.