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US 2025/0277784 A1Published application
Expression systems for the alpha6beta4 nicotinic acetylcholine receptor and methods of use thereof
OwnerDavid S Bredt, Shenyan Gu +4inventors
InventorsDavid S Bredt, Shenyan Gu, Jose Matta, Daniel Knowlan, Weston Davini, James Limberis
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Abstract
Disclosed herein are isolated recombinant cells for the expression of α6β4 nicotinic acetylcholine receptor (nAChR) and methods of use thereof.
Claims16
An isolated recombinant cell comprising:
- a) a heterologous nucleic acid encoding an α6 subunit of an α6β4 nicotinic acetylcholine receptor (nAChR);
- b) a heterologous nucleic acid encoding a β4 subunit of an α6β4 nAChR;
- and
- c) at least one heterologous nucleic acid selected from the group consisting of a heterologous nucleic acid encoding beta associated regulatory protein (BARP), a heterologous nucleic acid encoding choline O-acetyltransferase (CHAT), and a heterologous nucleic acid encoding sulfotransferase family 2B member 1 (SULT2B1).
1 more element
Dependencies are inferred from the claim text.