Recombinant rotavirus expressing exogenous protein and uses thereof
AssigneeThe Trustees of Indiana University
InventorsJohn Thomas PATTON, Asha Ann Philip
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Abstract
Disclosed herein are polynucleotides encoding recombinant rotaviruses (RVs), methods of using the same, and systems for generating the recombinant RVs.
Claims33
A polynucleotide comprising:
- a sequence encoding a rotavirus (RV) NSP3 protein;
- and
- a heterologous polynucleotide.
2-5. (canceled)
7-12. (canceled)
The polynucleotide of claim 12, wherein the peptide or protein comprises a norovirus (NoV) peptide or protein.
The polynucleotide of claim 12, wherein the peptide or protein comprises a SARS-CoV-2 protein or peptide.
19-21. (canceled)
The polynucleotide of claim 20, wherein the cleavage site is a self-cleaving peptide sequence.
24-25. (canceled)
27-28. (canceled)
The polynucleotide of claim 7, wherein the peptide or protein is a glycoprotein.
30-33. (canceled)
A polynucleotide encoding a protein selected from SEQ ID NOs:
- 2-11, or a sequence with at least about 90% identity to a sequence selected from SEQ ID NOs:
- 2-11.
A polynucleotide comprising any one of SEQ ID NOs:
- 13-22 or a sequence with at least about 90% identity to any one of SEQ ID NOs:
- 13-22.
40-43. (canceled)
45-48. (canceled)
50-58. (canceled)
60-62. (canceled)
64-69. (canceled)
Dependencies are inferred from the claim text.