Recombinant cedar virus chimeras
AssigneeThe Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
InventorsChristopher C. Broder, Moushimi Amaya
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Abstract
Described herein are replication-competent recombinant Cedar virus chimeras are described that are engineered to express antigenic surface or soluble proteins/polypeptides of a non-CedV henipavirus, such as of a pathogenic henipavirus, such as Nipah virus or Hendra virus. Vaccine compositions containing the recombinant Cedar virus chimeras are also described, as are therapeutic methods and uses for protecting against pathogenic henipavirus infection.
Claims24
A replication-competent recombinant Cedar virus (rCedV) chimera wherein one or both of the F and G envelope glycoprotein genes of CedV are replaced with one or both of the F and G envelope glycoprotein genes, respectively, of a non-CedV henipavirus.
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A replication-competent recombinant Cedar virus (rCedV) chimera, comprising the F and G envelope glycoprotein genes of CedV, further comprising a coding sequence for one or both of (i) a soluble F envelope glycoprotein (sF) of a non-CedV henipavirus, (ii) a soluble G envelope glycoprotein (sG) of a non-CedV henipavirus.
A replication-competent recombinant Cedar virus (rCedV) chimera, comprising one or both of (i) a gene encoding a henipavirus F envelope protein fusion protein, and (ii) a gene encoding a henipavirus G envelope protein fusion protein, wherein the fusion protein comprises the ectodomain and transmembrane domain of a non-CedV henipavirus F envelope protein or G envelope protein, respectively, fused to the cytoplasmic tail domain of CedV F envelope protein or G envelope protein, respectively, or the fusion protein comprises the ectodomain of a non-CedV henipavirus F envelope protein or G envelope protein, respectively, fused to the transmembrane domain and cytoplasmic tail domain of CedV F envelope protein or G envelope protein, respectively.
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Dependencies are inferred from the claim text.