Chicken-derived recombinant full-length monoclonal igy antibody against human thymidine kinase 1 and applications thereof

A chicken-derived recombinant full-length monoclonal IgY antibody against human tymidine kinase 1 (TK1), comprising a chicken-derived recombinant IgY single-chain antibody against human TK1 comprising:

• a heavy chain, comprising a first heavy chain variable region, a second heavy chain variable region and a third heavy chain variable region;
• a linkage peptide;
• and
• a light chain, comprising a first light chain variable region, a second light chain variable region and a third light chain variable region;
• wherein the first heavy chain variable region comprises the amino acid sequence selected from one of SEQ ID NO:
• 1 to SEQ ID NO:
• 3, the second heavy chain variable region comprises the amino acid sequence selected from one of SEQ ID NO:
• 4 to SEQ ID NO:
• 6, and the third heavy chain variable region comprises the amino acid sequence selected from one of SEQ ID NO:
• 7 to SEQ ID NO:
• 9;
• the first light chain variable region comprises the amino acid sequence selected from one of SEQ ID NO:
• 10 to SEQ ID NO:
• 14, the second light chain variable region comprises the amino acid sequence selected from one of SEQ ID NO:
• 15 to SEQ ID NO:
• 19, and the third light chain variable region comprises the amino acid sequence selected from one of SEQ ID NO:
• 20 to SEQ ID NO:
• 23.