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US 2025/0237641 A1Published application
Systems and methods for characterizing pathophysiology
AssigneeUniversity of Washington
InventorsBenjamin FREEDMAN, Louisa HELMS
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AssigneeUniversity of Washington
InventorsBenjamin FREEDMAN, Louisa HELMS
Estimating the term…
Systems and methods for culture of human kidney organoids as a model system for characterizing kidney pathologies and implementing therapeutics for conditions that affect the kidney. A model system for characterization of a pathophysiology includes a culture of human kidney organoids and an organoid culture medium. The organoids may include one or more genome edits as part of an approach for studying genetic factors involved with a pathological process. The culture may include one or more other factors, such as pathological agents and/or anti-pathological agents, for development and evaluation of therapeutics. The approaches may be used for implementation of compositions and methods for virally transducing the kidney or a subset of cells or cell types thereof.
A method for culturing a human kidney organoid as a model system for characterization of a pathogenesis, the method comprising:
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A model system for characterization of a pathogenesis, the model system comprising:
22-36. (canceled)
A method for characterizing a pathophysiology, the method comprising:
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A method to virally transduce a human kidney cell, the method comprising:
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A method for gene therapy of a mature kidney epithelium of a human kidney, the method comprising:
59-62. (canceled)
Dependencies are inferred from the claim text.