Method for predicting the postoperative risk of brain-injured patients and the use of steroids/proteins for predicting the postoperative risk of brain-injured patients
AssigneeTaipei Medical University
InventorChien-Ying Chuang
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Abstract
The present invention discloses a method for predicting the postoperative risk of brain-injured patients and a use of steroids/proteins for predicting the postoperative risk of brain-injured patients, mainly for testing the concentration of steroids/protein in patient samples. Acquire one-day in-vitro waste cerebrospinal fluid samples from brain-injured patients after surgery and conduct specific steroid and protein concentration tests. By confirming the concentration of specific steroid in the waste cerebrospinal fluid samples or the type and concentration of proteins detected therein, the postoperative risks of brain-injured patients can be predicted.
Claims13
A method for predicting the postoperative risks of brain-injured patients, comprising steps of:
- acquiring a clarified cerebrospinal fluid after centrifuging a waste cerebrospinal fluid sample;
- acquiring a steroid concentration by analyzing said clarified cerebrospinal fluid using a chromatography;
- and
- predicting a postoperative risk of a brain-injured patient according to said steroid concentration;
- wherein said steroid concentration is a 21-deoxycortisol concentration;
- and when said 21-deoxycortisol concentration is greater than 0.5 ng/mL, said brain-injured patient is predicted to have a high risk level.
A method for predicting the postoperative risks of brain-injured patients, comprising steps of:
- acquiring a clarified cerebrospinal fluid after centrifuging a waste cerebrospinal fluid sample;
- acquiring a steroid concentration by analyzing said clarified cerebrospinal fluid using an enzyme-linked immunosorbent assay;
- and
- predicting a postoperative risk of a brain-injured patient according to said steroid concentration;
- wherein said steroid concentration is a dehydroepiandrosterone concentration;
- and
- when said dehydroepiandrosterone concentration is less than 50 ng/mL, said brain-injured patient is predicted to have a high risk level.
A method for predicting the postoperative risks of brain-injured patients, comprising steps of:
- acquiring a clarified cerebrospinal fluid after centrifuging a waste cerebrospinal fluid sample;
- acquiring a test sample by performing a protein purification procedure on the clarified cerebrospinal fluid;
- and
- analyzing the types of proteins in the test sample using a protein immunoassay;
- and
- predicting a brain-injured patient to have a high risk level when said test sample contains a protein;
- wherein said protein is selected from the group consisting of an acetylated tubulin α, a myosin heavy chain 10, and a zinc finger protein 179.
A use of steroids for predicting the postoperative risks of brain-injured patients, wherein when a 21-deoxycortisol concentration in a waste cerebrospinal fluid sample is greater than 0.5 ng/mL, a brain-injured patient is predicted to have a high risk level;
- and said steroid is a 21-deoxycortisol.
A use of steroids for predicting the postoperative risks of brain-injured patients, wherein when a dehydroepiandrosterone concentration in a waste cerebrospinal fluid sample is less than 50 ng/mL, a brain-injured patient is predicted to have a high risk level;
- and said steroid is a dehydroepiandrosterone.
A use of proteins for predicting the postoperative risks of brain-injured patients, wherein when a waste cerebrospinal fluid sample contains a protein, a brain-injured patient is predicted to have a high risk level;
- and said protein is an acetylated tubulin α.
A use of proteins for predicting the postoperative risks of brain-injured patients, wherein when a waste cerebrospinal fluid sample contains a protein, a brain-injured patient is predicted to have a high risk level;
- and said protein is a myosin heavy chain 10.
A use of proteins for predicting the postoperative risks of brain-injured patients, wherein when a waste cerebrospinal fluid sample contains a protein, a brain-injured patient is predicted to have a high risk level;
- and said protein is a zinc finger protein 179.
Dependencies are inferred from the claim text.