Alphavirus replicon encoding chimeric sars-cov-2 receptor binding domains
AssigneeVLP Therapeutics, LLC
InventorsWataru AKAHATA, Jonathan F. SMITH, Ryuji UENO
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Abstract
Provided herein is an isolated polynucleotide, which encodes alphavirus non-structural proteins nsp1, nsp2, nsp3 and nsp4 and a polypeptide comprising a coronavirus protein fused to a signal sequence and/or transmembrane domain. The coronavirus protein may be the receptor binding domain of the S1 subunit of coronavirus spike (S) protein. The polynucleotide such as RNA is useful for as a vaccine against coronavirus infection, especially, COVID-19 infection.
Claims20
An isolated polynucleotide which encodes a polypeptide comprising a receptor binding domain (rbd) of an S1 subunit in a spike protein of a sars-cov-2 fused to a transmembrane domain and optionally to a signal sequence, wherein the transmembrane domain is heterologous to the sars-cov-2.
Dependencies are inferred from the claim text.