Treating orthopedic injury with a vector driving expression of acid ceramidase
AssigneeIcahn School of Medicine at Mount Sinai
InventorsEfrat ELIYAHU, Michael G. KATZ, Adam VINCEK
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to a method of treating an orthopedic condition, an orthopedic injury, or both in a subject in need of such treatment. The method includes administering a therapeutically effective amount of an adeno-associated viral vector to the subject. The adeno-associated viral vector transfects cells with a polynucleotide sequence that encodes and drives expression of an acid ceramidase. Also disclosed is a method of treating orthopedic inflammation in a subject in need of such treatment. The method includes administering a therapeutically effective amount of an adeno-associated viral vector that codes for expression of acid ceramidase to the subject.
Claims28
A method of treating an orthopedic condition, an orthopedic injury, or both in a subject in need of such treatment, comprising:
- administering a therapeutically effective amount of an adeno-associated viral vector to the subject, wherein the adeno-associated viral vector transfects cells with a polynucleotide sequence that encodes and drives expression of an acid ceramidase.
A method of treating orthopedic inflammation in a subject in need of such treatment, comprising:
- administering a therapeutically effective amount of an adeno-associated viral vector to the subject, wherein the adeno-associated viral vector transfects cells with a polynucleotide sequence that encodes and drives expression of an acid ceramidase.
Dependencies are inferred from the claim text.