Method for preparing t cells for adoptive t cell therapy
AssigneeSt. Jude Children's Research Hospital
InventorsDouglas R. GREEN, Hongbo CHI, Ao GUO, Hongling HUANG, Swantje LIEDMANN
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Abstract
Disclosed is a method for preparing T cells for adoptive T cell therapy by contacting a population of activated T cells with an AT-rich interaction domain 1A (Aridla) inhibitor. Also disclosed is a kit, a population of T cells or engineered T cells produced by the method and use of the same in adoptive T cell therapy and the treatment of cancer.
Claims18
A method for preparing T cells for adoptive T cell therapy comprising contacting a population of activated T cells with an AT-rich interaction domain 1A (Arid1a) inhibitor thereby preparing the T cells for adoptive T cell therapy.
A kit for preparing T cells for adoptive T cell therapy comprising
- (a) an AT-rich interaction domain 1A (Arid1a) inhibitor, and
- (b) a CD3 agonist.
Dependencies are inferred from the claim text.