Engineered invariant natural killer t (inkt) cells and methods of making and using thereof
AssigneeThe Regents of the University of California
InventorsLili Yang, Drake J. Smith
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Abstract
Disclosed herein are invariant natural killer T (iNKT) cells engineered using hematopoietic stem and progenitor cells (HSPCs) and methods of making and using thereof.
Claims13
A composition comprising an engineered cell having an exogenous invariant natural killer T cell receptor nucleic acid, wherein the engineered cell is derived from a progenitor cell into which has been incorporated the exogenous invariant natural killer T cell receptor nucleic acid and wherein the exogenous invariant natural killer T cell receptor nucleic acid is expressed as an invariant alpha chain polypeptide and a semi-invariant beta chain polypeptide.
Dependencies are inferred from the claim text.