Depsipeptides and uses thereof

An isolated compound of Formula (I):

• or an enantiomer, diastereomer, tautomer, or pharmaceutically acceptable salt thereof, wherein:
• each stereocenter is indicated with an “*” and may be, independently, either R or S configuration;
• each R1, R2′, R3′, R4′, R5′,and R6′ is independently selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, —NRbRb′, —CORc, —COORd, —CONReRe′ and an amino acid side chain;
• wherein each Ra, Ra′, Rb, Rb′, Rc, Rd, Re and Re′ is independently selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl and substituted or unsubstituted aryl;
• and
• n is an integer from 1 to 5.