3-o-sulfo-galactosylceramide analogs as activators of type ii nkt cells and uses thereof
AssigneesThe United States of America, as represented by the Secretary, Department of Health and Human Serv, University of Connecticut
InventorsLise H. Pasquet, Jay A. Berzofsky, Amy R. Howell, Masaki Terabe, Kaddy Camara, Stewart K. Richardson
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Abstract
Disclosed is a compound of the formula (I) or (II): wherein a-f are as described herein. The compounds are useful in the activation of Type II NKT cells and in treating cancer.
Claims18
A method of selectively activating type II natural killer T (NKT) cells in vitro, the method comprising:
- culturing in vitro a mononuclear cell fraction comprising one or more mammalian type II NKT cells in the presence of a composition comprising a compound or pharmaceutically acceptable salt of formula (I) or (II) in an amount sufficient to activate mammalian type II NKT cells in vitro, wherein
- formula (I) is
- and
- formula (II) is
- wherein a is an integer of from 1 to 20,
- b is 0 or 1,
- c is an integer of from 1 to 5,
- d is 0 or 1,
- e is an integer of from 1 to 10, and
- f is an integer of from 1 to 20,
- or a pharmaceutically acceptable salt thereof,
- with the provisos that:
- (i) when b is 1 and d is 0 in Formula (I), a+c+e≠20, and
- (ii) when b and d are both 0 in Formula (II), a+c+e≠22 or 14.
A method of inducing an immune response, treating cancer, inhibiting growth of a tumor, or inhibiting metastasis of a tumor in a mammal in need thereof, comprising administering to the mammal a composition comprising a compound or pharmaceutically acceptable salt of formula (I) or (II) in an amount effective to induce an immune response, treat cancer, inhibit growth of a tumor, or inhibit metastasis of a tumor in the mammal, wherein
- formula (I) is
- and
- formula (II) is
- wherein a is an integer of from 1 to 20,
- b is 0 or 1,
- c is an integer of from 1 to 5,
- d is 0 or 1,
- e is an integer of from 1 to 10, and
- f is an integer of from 1 to 20,
- or a pharmaceutically acceptable salt thereof,
- with the provisos that:
- (i) when b is 1 and d is 0 in Formula (I), a+c+e≠20, and
- (ii) when b and d are both 0 in Formula (II), a+c+e≠22 or 14.
Dependencies are inferred from the claim text.