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US 2025/0222000 A1Published application
Uridine Phosphorylase Inhibitors to Treat or Prevent Pulmonary Disease
AssigneeTosk, Inc.
InventorsWilliam A. Garland, Philip Liaw, Brian D. Frenzel
Life of this patent
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Abstract
The present invention relates to compositions, formulations, and methods for treating pulmonary disorders having fibrosis as part of the underlying pathology, such as IPF and ARDS, by administration of a UPase inhibitor, with or without supplemental UR, a UR prodrug, or a UR mimetic to a subject in need thereof.
Claims24
1-16. (canceled)
A method of treating a subject for pulmonary condition having a toxic hepatic pathology, the method comprising:
- administering to the subject an effective amount of a 2,2′-anhydropyrimidine or derivative thereof in combination with one or more of UR, an UR prodrug and an UR mimetic to treat the subject for the pulmonary condition.
27-31. (canceled)
34-35. (canceled)
(canceled)
Dependencies are inferred from the claim text.