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US 2025/0221977 A1Published application
Novel benzothiophene derivative and use thereof as bet inhibitor
AssigneeBenoBio Co., Ltd
InventorIn Hyun LEE
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Abstract
The present invention relates to a novel benzothiophene derivative and use thereof as a bromodomain extra-terminal (BET) inhibitor, and, more specifically, to a novel benzothiophene derivative compound of the following chemical formula 1 having inhibitory activity against a BET protein, and a pharmaceutical composition comprising same for preventing or treating BET protein-associated diseases.
Claims20
A compound represented by Chemical Formula 1 below or a pharmaceutically acceptable salt thereof:
- wherein,
- X or Y is each independently H, halo, cyano, alkyl, alkenyl, alkynyl, —(Ra)C(═O)Rb, —(Ra)C(═O)N(Rb)(Rc), —(Ra)C(═O)ORb, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, pyridine, alkyl pyridine, piperidine, piperidinopyridine, indazole, or,
- Z is the same or different one or more selected from the group consisting of H, C1-C6 alkyl, —ORa, —SRa, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, pyridine, pyrazole, alkylpyrazole, and hydroxypyridine,
- Ra, Rb and Rc are each independently H, alkyl, or alkylene, and
- R1 is H, halo, cyano, alkyl, alkenyl, alkynyl, or halogenated methyl.
2 more elements
Dependencies are inferred from the claim text.