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US 2025/0214979 A1Published application
Compounds for treating psychostimulant misuse
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsChristopher R. McCurdy, Sarah Mallory Burns, Shelby Tyler Green
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Abstract
Described herein are new dual sigma receptor and dopamine transporter small molecule antagonists. As these compounds are antagonists of both sigma receptors and dopamine transporters, these compounds dose-dependently antagonize stimulant self-administration and also diminish the effects of stimulant effects on dopamine level, thus indicating minimal abuse liability.
Claims37
A compound of Formula (I):
- or pharmaceutically acceptable salt thereof, wherein:
- Z is O, S, NRN, or C(RC)2;
- each RN is independently hydrogen, C1-6 alkyl, or a nitrogen protecting group;
- each RC is independently hydrogen or C1-6 alkyl;
- Y is O, S, NRN, or C(RC)2;
- R1 hydrogen, halogen, substituted or unsubstituted C1-12 alkyl;
- R2 hydrogen, halogen, substituted or unsubstituted C1-12 alkyl;
- L is substituted or unsubstituted C1-12 alkylene or substituted or unsubstituted hetero-C1-12-alkylene;
- RH is selected from the group consisting of:
- Ar1 is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
- n is an integer selected from 1, 2, 3, 4, and 5;
- each R3 is independently selected from the group consisting of hydrogen, halogen, —NO2, —CN, —C(═O)RC, and —C(═O)ORC;
- each R4 is independently hydrogen or C1-6 alkyl;
- and
- m is an integer selected from 0, 1, 2, 3, 4, and 5.
12 more elements
Dependencies are inferred from the claim text.