3,4-dihydroquinoxaline-2-carboximide derivative compound and pharmaceutical composition comprising same for preventing or treating cancer disease

A method of preparing a compound represented by Chemical Formula 1, comprising:

• as shown in the following Reaction Scheme 1,
• reacting a compound represented by Chemical Formula 1A with a hydroxide ion (OH—) to prepare a compound represented by Chemical Formula 1B;
• and
• reacting the compound represented by Chemical Formula 1B with a compound represented by Chemical Formula 1C to prepare a compound represented by Chemical Formula 1,
• wherein, in the Reaction Scheme 1,
• R1 is unsubstituted or substituted C5-8cycloalkyl, unsubstituted or substituted C6-10aryl, unsubstituted or substituted heteroaryl of 5 to 8 atoms containing one or more heteroatoms selected from the group consisting of N, O and S, unsubstituted or substituted fused heteroaryl of 8 to 10 atoms containing one or more heteroatoms selected from the group consisting of N, O and S, or C1-15alkenyl,
• wherein the substituted C5-8cycloalkyl is substituted with one or more substituents selected from the group consisting of halogen, —CONH—OH, —CH2—CONH—OH, —CH2CH2—CONH—OH, C1-10alkyl, C1-10alkoxy, C1-10haloalkyl, C1-8alkoxycarbonyl, C1-8alkoxycarbonylC1-8alkyl, and C1-8alkylcarbonyloxy,
• the substituted C6-10aryl is substituted with one or more substituents selected from the group consisting of halogen, —CONH—OH, —CH2—CONH—OH, —CH2CH2—CONH—OH, C1-10alkyl, C1-10alkoxy, C1-10haloalkyl, C6-10aryl, C1-8alkoxycarbonyl, C1-8alkoxycarbonylC1-8alkyl, C1-8alkylcarbonyloxy, and heteroaryl of 5 to 8 atoms containing one or more heteroatoms selected from the group consisting of N, O and S,
• the substituted heteroaryl of 5 to 8 atoms is substituted with halogen, or C6-10aryl substituted with halogen, and
• the substituted fused heteroaryl of 8 to 10 atoms is substituted with one or more substituents selected from the group consisting of —OH, halogen, C1-8alkoxycarbonyl, C1-8alkoxycarbonylC1-5alkyl, and C1-8alkylcarbonyloxy;
• R2 and R3 are each independently —H, halogen, or C1-10alkyl;
• R4 is C1-8alkyl, or C3-10alkyl substituted with two or more —OH;
• and
• L1 is a bond, or C1-10alkylene.