Method for purifying levetiracetam intermediate
AssigneeZhejiang Huahai Pharmaceutical Co., Ltd.
InventorsFengfeng YAN, Hui CHEN, Yulong GONG, Yuanxun ZHU
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Abstract
The present invention relates to the field of pharmaceutical chemical engineering, in particular to a method for purifying a levetiracetam intermediate, which comprises the following steps: (1) hydrolyzing and acidifying a crude product of a compound of formula III and performing crystallization to obtain a compound of formula IV; and (2) subjecting the compound of formula IV to an esterification reaction and separation to obtain a purified compound of formula III. The present method has a purification effect obviously superior to that of a physical purification mode, can reach a total yield of 90% or above, and has a great practical value.
Claims10
A method for purifying a levetiracetam intermediate, wherein the method comprises the following steps:
- (1) hydrolyzing a crude product of a compound of formula III under alkaline conditions, followed by acidifying, then crystallizing to obtain a compound of formula IV;
- and
- (2) subjecting the compound of formula IV to an esterification reaction, followed by separation, to obtain a purified compound of formula III;
- wherein the compound of formula III is
- R is methyl or ethyl, and the compound of formula IV is
Dependencies are inferred from the claim text.