US 2025/0213680 A1 · LIPID NANOPARTICLE COMPOSITION COMPRISING GALLIC ACID DERIVATIVE LIPID AND USE THEREOF

Abstract

The present disclosure relates to a lipid nanoparticle composition including a gallic acid derivative lipid and a use thereof, wherein it is possible to improve delivery efficiency and immune effect by changing some of the compositions of lipid nanoparticles using a bio-friendly gallic acid derivative lipid and, in particular, if a gallic acid derivative replaces a certain ratio of an ionizable lipid in a molar composition ratio, it is possible to mitigate toxicity generated by the ionizable lipid, so as to be utilized for drug delivery more safely in vivo.

Claims18

Dependent claims

A method of delivering a nucleic acid to a cell in a subject, comprising:

administering a lipid nanoparticle composition comprising a compound represented by the following Chemical Formula 1, a derivative thereof, or a pharmaceutically acceptable salt thereof as an active ingredient and the nucleic acid to the subject:
wherein, in the Chemical Formula 1,
R is a linear, saturated or unsaturated hydrocarbon with 3 to 22 carbon atoms.

Dependencies are inferred from the claim text.

Facts

Application

19/000,614Filed 23 Dec 2024

Priority

KR 10-2023-019534228 Dec 2023

Published

3 Jul 2025

Term ends

Not estimatedThe source records don’t support an estimate.

Classification15 codes

A61K 39/39
Medicinal preparations containing antigens or antibodies: characterised by the immunostimulating additives, e.g. chemical adjuvants
A61K 9/1271
Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant: non-conventional liposomes,…
A61K 9/5123
Excipients; Inactive ingredients: organic compounds, e.g. fats, sugars
A61K 39/12
Medicinal preparations containing antigens or antibodies: viral antigens

Lipid nanoparticle composition comprising gallic acid derivative lipid and use thereof

Life of this patent

Lipid nanoparticle composition comprising gallic acid derivative lipid and use thereof

Life of this patent

Abstract

Claims18