US 2025/0213643 A1 · COMPOSITIONS AND METHOD FOR OPTIMIZED PEPTIDE VACCINES USING RESIDUE OPTIMIZATION

A method of preventing or treating cancer in a human subject, the method comprising administering an effective amount of an immunogenic composition, wherein the immunogenic composition comprises at least one isolated polynucleotide encoding at least one amino acid sequence selected from the group consisting of SEQ ID NO:

158, SEQ ID NO:
161, SEQ ID NO:
162, SEQ ID NO:
163, SEQ ID NO:
164, SEQ ID NO:
165, SEQ ID NO:
7882, SEQ ID NO:
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7887, SEQ ID NO:
7888, SEQ ID NO:
7894, SEQ ID NO:
7920, SEQ ID NO:
7921, SEQ ID NO:
7933, SEQ ID NO:
7934, SEQ ID NO:
7940, SEQ ID NO:
7950, SEQ ID NO:
7951, SEQ ID NO:
7970, SEQ ID NO:
7972, SEQ ID NO:
7976, SEQ ID NO:
7982, SEQ ID NO:
8080, SEQ ID NO:
8139, SEQ ID NO:
8267, SEQ ID NO:
8269, SEQ ID NO:
8272, SEQ ID NO:
8277, SEQ ID NO:
8296, and SEQ ID NO:
8422.

27 more elements

A method of preventing or treating cancer in a human subject, the method comprising administering an effective amount of an immunogenic composition, wherein the immunogenic composition comprises at least one isolated polynucleotide encoding at least one amino acid sequence selected from the group consisting of SEQ ID NO:

209, SEQ ID NO:
210, SEQ ID NO:
211, SEQ ID NO:
11018, SEQ ID NO:
11021, SEQ ID NO:
11024, SEQ ID NO:
11053, SEQ ID NO:
11054, SEQ ID NO:
11064, SEQ ID NO:
11072, SEQ ID NO:
11073, SEQ ID NO:
11078, SEQ ID NO:
11079, SEQ ID NO:
11080, SEQ ID NO:
11092, SEQ ID NO:
11094, SEQ ID NO:
11097, SEQ ID NO:
11102, SEQ ID NO:
11106, SEQ ID NO:
11108, SEQ ID NO:
11116, SEQ ID NO:
11118, SEQ ID NO:
11122, SEQ ID NO:
11128, SEQ ID NO:
11130, SEQ ID NO:
11193, SEQ ID NO:
11203, SEQ ID NO:
11206, SEQ ID NO:
11212, SEQ ID NO:
11220, SEQ ID NO:
11227, SEQ ID NO:
11274, SEQ ID NO:
11283, SEQ ID NO:
11305, SEQ ID NO:
11306, SEQ ID NO:
11310, SEQ ID NO:
11311, SEQ ID NO:
11315, SEQ ID NO:
11324, SEQ ID NO:
11333, SEQ ID NO:
11342, SEQ ID NO:
11343, SEQ ID NO:
11352, SEQ ID NO:
11453, SEQ ID NO:
11456, SEQ ID NO:
11457, SEQ ID NO:
11461, SEQ ID NO:
11465, SEQ ID NO:
11468, SEQ ID NO:
11469, SEQ ID NO:
11474, SEQ ID NO:
11585, SEQ ID NO:
11617, SEQ ID NO:
11672, SEQ ID NO:
11701, SEQ ID NO:
11723, and SEQ ID NO:
11734.

54 more elements

A method of preventing or treating cancer in a human subject, the method comprising administering an effective amount of an immunogenic composition, wherein the immunogenic composition comprises at least one isolated polynucleotide encoding at least one amino acid sequence selected from the group consisting of SEQ ID NO:

183, SEQ ID NO:
188, SEQ ID NO:
189, SEQ ID NO:
190, SEQ ID NO:
9760, SEQ ID NO:
9768, SEQ ID NO:
9771, SEQ ID NO:
9772, SEQ ID NO:
9775, SEQ ID NO:
9776, SEQ ID NO:
9779, SEQ ID NO:
9780, SEQ ID NO:
9784, SEQ ID NO:
9785, SEQ ID NO:
9795, SEQ ID NO:
9799, SEQ ID NO:
9844, SEQ ID NO:
9872, SEQ ID NO:
9875, SEQ ID NO:
9877, SEQ ID NO:
9878, SEQ ID NO:
9907, SEQ ID NO:
9914, SEQ ID NO:
9920, SEQ ID NO:
9927, SEQ ID NO:
9933, SEQ ID NO:
9940, SEQ ID NO:
10072, SEQ ID NO:
10075, SEQ ID NO:
10076, SEQ ID NO:
10079, SEQ ID NO:
10103, SEQ ID NO:
10192, and SEQ ID NO:
10227.

31 more elements

A method of preventing or treating cancer in a human subject, the method comprising administering an effective amount of an immunogenic composition, wherein the immunogenic composition comprises at least one isolated polynucleotide encoding at least one amino acid sequence selected from the group consisting of SEQ ID NO:

170, SEQ ID NO:
171, SEQ ID NO:
173, SEQ ID NO:
174, SEQ ID NO:
175, SEQ ID NO:
176, SEQ ID NO:
177, SEQ ID NO:
8439, SEQ ID NO:
8447, SEQ ID NO:
8464, SEQ ID NO:
8465, SEQ ID NO:
8467, SEQ ID NO:
8468, SEQ ID NO:
8472, SEQ ID NO:
8475, SEQ ID NO:
8498, SEQ ID NO:
8504, SEQ ID NO:
8510, SEQ ID NO:
8513, SEQ ID NO:
8514, SEQ ID NO:
8518, SEQ ID NO:
8524, SEQ ID NO:
8526, SEQ ID NO:
8534, SEQ ID NO:
8554, SEQ ID NO:
8605, SEQ ID NO:
8630, SEQ ID NO:
8631, SEQ ID NO:
8667, SEQ ID NO:
8669, SEQ ID NO:
8671, SEQ ID NO:
8672, SEQ ID NO:
8675, SEQ ID NO:
8704, SEQ ID NO:
8705, SEQ ID NO:
8707, SEQ ID NO:
8708, SEQ ID NO:
8710, SEQ ID NO:
8731, SEQ ID NO:
8733, SEQ ID NO:
8734, SEQ ID NO:
8736, SEQ ID NO:
8764, SEQ ID NO:
8828, SEQ ID NO:
8831, SEQ ID NO:
8841, SEQ ID NO:
8847, SEQ ID NO:
8849, SEQ ID NO:
8851, SEQ ID NO:
8852, SEQ ID NO:
8855, SEQ ID NO:
8863, SEQ ID NO:
8878, SEQ ID NO:
8880, SEQ ID NO:
8882, SEQ ID NO:
8883, SEQ ID NO:
8886, SEQ ID NO:
8898, SEQ ID NO:
8909, SEQ ID NO:
8911, SEQ ID NO:
8913, SEQ ID NO:
8914, SEQ ID NO:
8917, SEQ ID NO:
8958, SEQ ID NO:
9059, SEQ ID NO:
9066, SEQ ID NO:
9067, SEQ ID NO:
9070, SEQ ID NO:
9072, SEQ ID NO:
9073, SEQ ID NO:
9075, SEQ ID NO:
9076, SEQ ID NO:
9083, SEQ ID NO:
9085, SEQ ID NO:
9086, SEQ ID NO:
9103, SEQ ID NO:
9106, SEQ ID NO:
9107, SEQ ID NO:
9112, SEQ ID NO:
9221, SEQ ID NO:
9222, SEQ ID NO:
9279, SEQ ID NO:
9280, SEQ ID NO:
9282, SEQ ID NO:
9286, SEQ ID NO:
9287, SEQ ID NO:
9293, SEQ ID NO:
9336, SEQ ID NO:
9340, SEQ ID NO:
9341, SEQ ID NO:
9345, SEQ ID NO:
9368, SEQ ID NO:
9371, SEQ ID NO:
9375, SEQ ID NO:
9376, SEQ ID NO:
9381, SEQ ID NO:
9393, SEQ ID NO:
9412, SEQ ID NO:
9425, SEQ ID NO:
9458, SEQ ID NO:
9481, SEQ ID NO:
9486, SEQ ID NO:
9491, SEQ ID NO:
9538, SEQ ID NO:
9543, SEQ ID NO:
9544, SEQ ID NO:
9546, SEQ ID NO:
9550, SEQ ID NO:
9551, SEQ ID NO:
9558, SEQ ID NO:
9587, SEQ ID NO:
9591, SEQ ID NO:
9592, SEQ ID NO:
9594, SEQ ID NO:
9598, SEQ ID NO:
9599, SEQ ID NO:
9606, SEQ ID NO:
9626, SEQ ID NO:
9633, SEQ ID NO:
9637, SEQ ID NO:
9642, SEQ ID NO:
9643, SEQ ID NO:
9645, SEQ ID NO:
9649, SEQ ID NO:
9650, SEQ ID NO:
9657, SEQ ID NO:
9698, and SEQ ID NO:
9721.

125 more elements

Compositions and method for optimized peptide vaccines using residue optimization

Life of this patent

Compositions and method for optimized peptide vaccines using residue optimization

Life of this patent

Abstract

Claims30