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US 2025/0213473 A1Published application
Highly transparent water continuous dense nanolipid fluid (dnlf) dispersions and method of preparation using a twin screw extruder
OwnerEric Morrisoninventor
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Abstract
The present invention provides a method of preparing a lipid nanoparticle dispersion using a twin screw extruder. The inventive DNLF fluids are isotropic fluids which include greater than 25% lipophilic content in the form of lipidic nanoparticles dispersed in a continuous aqueous matrix with turbidity less than 375 nephelometric turbidity units (NTU).
Claims21
1-22. (canceled)
A lipid nanoparticle dispersion comprising:
- from 11.1 to 19.8 wt. % of one or more polyethoxylated high hydrophile-lipophile-balance (HLB) surfactants;
- from 3.3 to 10.1 wt. % of one or more low hydrophile-lipophile-balance (HLB) surfactants;
- one or more water immiscible oils;
- and
- water,
- wherein the lipid nanoparticle dispersion has a lipophilic concentration greater than about 25%, a volume average particle size less than about 100 nm, and a turbidity less than 375 nephelometric turbidity units (NTU) at room temperature.
3 more elements
The lipid nanoparticle dispersion of claim 12, wherein the one or more water immiscible oils comprises mineral oil.
Dependencies are inferred from the claim text.