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US 2025/0212929 A1Published application
Nutritional composition
AssigneesN.V. Nutricia, Nutricia Early Life Nutrition (Shanghai) Co., Ltd.
InventorsSebastian Tims, Thomas Ludwig, Guus Roeselers, Jan Knol, Gregg Ward, Haofang Jin
Life of this patent
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Abstract
A nutritional composition comprising sn-2 palmitic acid and A2 beta-casein for use in improving the gut microbiota in a human subject.
Claims22
A method for improving gut microbiota in a human subject, said method comprising the administration of a nutritional composition comprising:
- a. 10-50 wt. % lipid component, by dry weight, said lipid component containing at least 5 wt. % palmitic acid based on total fatty acids and at least 15 wt. % of palmitic acid, based on total palmitic acid, is located at the sn-2 position of a triglyceride, wherein the composition comprises at least 70 wt. % triglycerides, based on the lipid components;
- and
- b. 5-20 wt. % protein by dry weight of the composition, wherein 1-50 wt. % beta-casein by weight of total protein, wherein at least 75% by weight of the beta-casein is a beta-casein variant that has a proline at position 67 of the beta-casein amino acid sequence;
- wherein the method for improving gut microbiota encompasses reducing Proteobacteria.
1 more element
-6. (canceled)
A nutritional composition comprising:
- a. 10-50 wt. % lipid component by dry weight of the composition, wherein the lipid component contains at least 5 wt. % palmitic acid based on total fatty acids and at least 15 wt. % of the palmitic acid, based on total palmitic acid, is in the sn-2 position of a triglyceride, wherein the composition comprises at least 70 wt. % triglycerides, based on the lipid component;
- b. 5-20 wt. % protein by dry weight of the composition, from which:
- i. 1-50 wt. % is beta-casein, wherein at least 75% by weight of the beta-casein is a beta-casein variant that has a proline at position 67 of the beta-casein amino acid sequence;
- ii. 0.05-5 wt. % is lactoferrin;
- c. 20-80 wt. % digestible carbohydrates by dry weight of the composition;
- d. 2-12 wt. % non-digestible carbohydrates by dry weight of the composition;
- and
- e. 104-1012 cfu probiotic bacteria per 100 g in dry weight.
5 more elements
-20. (canceled)
Dependencies are inferred from the claim text.