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US 2025/0207162 A1Published application
Culture conditions for high production of antibiotic compound aureothin from Streptomyces thioluteus
OwnerByung-Kwan Cho, Woori Kim +2inventors
InventorsByung-Kwan Cho, Woori Kim, Jihun Kim, Soonkyu Hwang
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Abstract
The present invention relates to culture conditions for high production of the antibiotic aureothin from Streptomyces thioluteus.
Claims5
A method for producing an antibiotic, the method comprising:
- culturing Streptomyces thioluteus in a medium containing a specific composition;
- and recovering an antibiotic from the cultured microorganism or medium,
- wherein the medium contains any one composition of (1) to (4) below:
- (1) sucrose 103 g/L, K2SO4 0.25 g/L, MgCl2·6H2O 10.12 g/L, glucose 10 g/L, casamino acids 0.1 g/L, yeast extract 5 g/L, and N-[tris(hydroxymethyl)methyl]-2-aminoethanesulfonic acid (TES) buffer 5.73 g/L;
- (2) yeast extract 4 g/L, malt extract 10 g/L, and maltose 4 g/L;
- (3) yeast extract 4 g/L, malt extract 10 g/L, and glucose 4 g/L;
- and
- (4) soluble starch 10 g/L, glucose 20 g/L, soy peptone 25 g/L, beef extract 1 g/L, yeast extract 4 g/L, sodium chloride 2 g/L, and calcium carbonate 2 g/L.
5 more elements
A culture method for increasing the production of an antibiotic from Streptomyces thioluteus, the method comprising culturing Streptomyces thioluteus in a medium containing any one composition of (1) to (4) below:
- (1) sucrose 103 g/L, K2SO4 0.25 g/L, MgCl2·6H2O 10.12 g/L, glucose 10 g/L, casamino acids 0.1 g/L, yeast extract 5 g/L, and N-[tris(hydroxymethyl)methyl]-2-aminoethanesulfonic acid (TES) buffer 5.73 g/L;
- (2) yeast extract 4 g/L, malt extract 10 g/L, and maltose 4 g/L;
- (3) yeast extract 4 g/L, malt extract 10 g/L, and glucose 4 g/L;
- and
- (4) soluble starch 10 g/L, glucose 20 g/L, soy peptone 25 g/L, beef extract 1 g/L, yeast extract 4 g/L, sodium chloride 2 g/L, and calcium carbonate 2 g/L.
2 more elements
Dependencies are inferred from the claim text.