Nitric oxide generation systems and methods

A nitric oxide (NO) gas generation system, the system comprising:

• a first reservoir configured to contain a first solution, the first solution comprising a nitrite source;
• a second reservoir configured to contain a second solution, the second solution comprising an acidic solution;
• a first flow generator in fluid communication with the first reservoir;
• a second flow generator in fluid communication with the second reservoir;
• a housing configured to contain a reaction chamber and a gas chamber, the gas chamber separated from the reaction chamber by a gas-permeable membrane, the reaction chamber disposed downstream of and in fluid communication with the first flow generator and the second flow generator;
• a carrier gas source disposed upstream of and in fluid communication with the gas chamber;
• a liquid separation tank disposed downstream of and in fluid communication with the reaction chamber, the liquid separation tank having a first outlet and a second outlet;
• a first circulation circuit disposed downstream of and in fluid communication with the first outlet of the liquid separation tank and disposed upstream of and in fluid communication with the reaction chamber;
• a waste storage unit disposed downstream of and in fluid communication with the second outlet of the liquid separation tank;
• a treatment module disposed downstream of and in fluid communication with the gas chamber of the housing, the treatment module comprising
• a treatment chamber configured to contain the product gas and cover at least a portion of a treatment site;
• a gas treatment unit disposed downstream of the treatment chamber and configured to absorb NO gas;
• and
• a second circulation circuit configured to generate a fluid flow relative to the treatment chamber.