Novel plant virus and bacteriophage vaccines
AssigneeThe Regents of the University of California
InventorsNicole F. Steinmetz, Young Hun Chung
Life of this patent
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Abstract
This disclosure provides a conjugate comprising a bacteriophage, plant virus or viral nanoparticle (VNP) conjugated to an antigen or antigenic peptide.
Claims27
A method of making a vaccine conjugate comprising conjugating a bacteriophage QBeta (“QB”) or virus nanoparticle (VNP) having one or more external lysines to a histidine-tagged antigen or antigenic peptide with a nickel nitrilotracetic acid linker (NiNTA linker), wherein the NiNTA linker binds the histidine-tagged antigen or antigenic peptide to one or more external lysines on the bacteriophage QB or VNP.
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A conjugate comprising:
- 1) a bacteriophage QBeta (“QB”) or virus nanoparticle (VNP) wherein the VNP is or is derived from a plant virus, having one or more external lysines;
- 2) a histidine-tagged antigen or antigenic peptide;
- and 3) a nickel nitrilotracetic acid linker (NiNTA linker), wherein the NiNTA linker binds the histidine-tagged antigen or antigenic peptide to one or more external lysines on the bacteriophage QB or VNP.
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Dependencies are inferred from the claim text.