Targeting e coli cells
AssigneeSNIPR Biome ApS
InventorsJakob KRAUSE HAABER, Szabolcs SEMSEY, Mette GROVE, Birgitte DAMHOLT, Dziuginta JASINSKYTE, Yilmaz Emre GENÇAY
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Abstract
The technology described herein relates to methods and compositions for targeting E coli cells, such as for treating or preventing an infection by E coli cells in human or animal subjects. The method, in an embodiment, comprises administering to the subject a particle cocktail comprising a plurality of different transduction particles to E coli cells. The method, in an embodiment, comprises administering to the subject a plurality of transduction particles that encode a nuclease for targeting the genomes of B2 phylogroup E coli cells.
Claims21
1-60. (canceled)
A composition comprising a first type of transduction particle comprising
- (a) a nucleic acid encoding a Cas, wherein expression of the Cas is under control of (i) an E. coli BolA promoter comprising the nucleotide sequence set forth in SEQ ID NO:
- 13 and (ii) an E. coli J23100 promoter comprising the nucleotide sequence set forth in SEQ ID NO:
- 14;
- and
- (b) a T-even phage capsid.
Dependencies are inferred from the claim text.