Anandamide cyclodextrin inclusion complex vehicles
AssigneeCZAP Research and Development LLC
InventorAl Czap
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Abstract
The invention provides oral cyclodextrin inclusion complex formulations in which an anandamide cyclodextrin inclusion complex is provided together with enzyme having a cyclodextrin-degrading activity capable of digesting the cyclodextrin, so that upon delivery of the formulation to a target tissue the enzyme is activated and releases the anandamide from the cyclodextrin cavity. In alternative aspects, these cyclodextrin inclusion complex formulations are provided in the form of time release formulations, treating or preventing a nitric oxide deficiency or a disease which can be treated or prevented by increasing endogenous nitric oxide levels in a mammal.
Claims52
A method of treating or preventing a nitric oxide deficiency or a disease which can be treated or prevented by increasing endogenous nitric oxide levels in a mammal, or of increasing endogenous nitric oxide levels in a mammal, or of increasing the cardiovascular performance of a mammal, comprising orally administering to the mammal an effective amount of a cyclodextrin (CD) inclusion complex formulation, comprising:
- anandamide or an analogue thereof as a guest molecule in the CD;
- and, a co-formulated cyclodextrin degrading enzyme.
A cyclodextrin (CD) inclusion complex formulation, comprising:
- anandamide or an analogue thereof as a guest molecule in the CD;
- and, a co-formulated cyclodextrin degrading enzyme.
Dependencies are inferred from the claim text.