# US 2025/0204792 A1 · Hemodynamic monitor for triaging patients with aortic stenosis > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2025/0204792 A1 - Document ID: US20250204792A1 - Status: Published application - Kind: A1 - Application number: 19/080,399 - Filed: 2025-03-14 - Published: 2025-06-26 - Earliest claimed: 2022-09-15 - Assignees: Becton, Dickinson and Company - Applicants: Becton, Dickinson and Company - Inventors: Arghavan Arafati; Cristhian M. Potes Blandon; Feras Al Hatib; Sai Prasad Buddi - Web page: https://patentgrep.com/patent/US20250204792A1 ## CPC - A61B 5/02007: {Evaluating blood vessel condition, e.g. elasticity, compliance} - A61B 5/02028: {Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction} - A61B 5/02108: {from analysis of pulse wave characteristics} - A61B 5/0215: by means inserted into the body - A61B 5/022: by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers - A61B 5/02255: {the pressure being controlled by plethysmographic signals, e.g. derived from optical sensors} - A61B 5/029: Measuring blood output from the heart, e.g. minute volume - A61B 5/4842: {Monitoring progression or stage of a disease} - A61B 5/7267: {involving training the classification device} - A61B 5/7275: {Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor} - A61B 5/742: {using visual displays (displays for heart-related electrical signals, e.g. ECG, A61B5/339)} - A61B 5/746: {Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms} - G16H 40/63: for local operation - G16H 50/70: for mining of medical data, e.g. analysing previous cases of other patients - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA ## Abstract A hemodynamic monitor for detecting aortic stenosis includes a non-invasive blood pressure sensor and an integrated hardware unit with a system processor, a system memory, and a display with a user interface. The system memory includes instructions that, when executed by the system processor, are configured to adjust, by a pressure controller, a pressure within an inflatable blood pressure bladder. An arterial pressure waveform data of the patient is generated based on the adjusted pressure within the inflatable blood pressure bladder over the period of time and a plurality of signal measures are extracted from the arterial pressure waveform data of the patient. Input features are extracted from the plurality of signal measures that are indicative of an aortic stenosis score of the patient, and the aortic stenosis score of the patient is determined based on the extracted input features. ## Claims ### Claim 1 A hemodynamic monitor for detecting aortic stenosis, the hemodynamic monitor comprising: a non-invasive blood pressure sensor comprising an inflatable blood pressure bladder, a pressure controller pneumatically connected to the inflatable blood pressure bladder, and an optical transmitter and an optical receiver that are electrically connected to the pressure controller; an integrated hardware unit comprising: a system processor; a system memory; a display comprising a user interface; and wherein the system memory comprises instructions that, when executed by the system processor, are configured to: adjust, by the pressure controller, a pressure within the inflatable blood pressure bladder to maintain a constant volume of an artery of a patient for a period of time based on a feedback signal generated by the optical transmitter and the optical receiver; generate an arterial pressure waveform data of the patient based on the adjusted pressure within the inflatable blood pressure bladder over the period of time; extract a plurality of signal measures from the arterial pressure waveform data of the patient; extract input features from the plurality of signal measures that are indicative of an aortic stenosis score of the patient; determine the aortic stenosis score of the patient based on the extracted input features; generate a first sensory alarm signal configured to generate a first sensory alert that indicates that the patient has severe aortic stenosis when the aortic stenosis score exceeds a threshold score, or generate a second sensory alarm signal configured to generate a second sensory alert that indicates that the patient does not have severe aortic stenosis when the aortic stenosis score is below the threshold score; transmit the first sensory alarm signal or the second sensory alarm signal to the user interface; and output the first sensory alert or the second sensory alert through the user interface. ### Claim 2 (depends on 1) The hemodynamic monitor of claim 1, wherein the input features are determined by machine training, wherein the machine training comprises: collecting a first clinical dataset containing arterial pressure waveforms from a first group of individuals with normal aortic valve function; collecting a second clinical dataset containing arterial pressure waveforms from a second group of individuals with severe aortic stenosis, wherein severe aortic stenosis is defined as an aortic valve area less than 1 cm2; collecting a third clinical dataset containing arterial pressure waveforms from a third group of individuals with mild aortic stenosis, wherein mild aortic stenosis is defined as an aortic valve area greater than 1.5 cm2; collecting a fourth clinical dataset containing arterial pressure waveforms from a fourth group of individuals with moderate aortic stenosis, wherein moderate aortic stenosis is defined as an aortic valve area between 1 cm2 and 1.5 cm2; performing waveform analysis of the arterial pressure waveforms of the first clinical dataset, the second clinical dataset, the third clinical dataset, and the fourth clinical dataset to calculate a plurality of waveform signal measures; and determining the input features by computing combinatorial measures between the plurality of waveform signal measures and selecting top signal measures from the plurality of waveform signal measures with most predictive combinatorial measures and labeling the top signal measures as the input features. ### Claim 3 (depends on 2) The hemodynamic monitor of claim 2, wherein performing waveform analysis of the arterial pressure waveforms of the first clinical dataset, the second clinical dataset, the third clinical dataset, and the fourth clinical dataset to calculate the plurality of waveform signal measures comprises: identifying individual cardiac cycles in each of the arterial pressure waveforms of the first clinical dataset, the second clinical dataset, the third clinical dataset, and the fourth clinical dataset; identifying a dicrotic notch in each of the individual cardiac cycles; identifying a systolic rise phase, a systolic decay phase, and a diastolic phase in each of the individual cardiac cycles; and extracting the plurality of waveform signal measures from each of the systolic rise phase, the systolic decay phase, and the diastolic phase from each of the individual cardiac cycles. ### Claim 4 (depends on 3) The hemodynamic monitor of claim 3, wherein the plurality of waveform signal measures corresponds to hemodynamic effects from each of the systolic rise phase, the systolic decay phase, and the diastolic phase from each of the individual cardiac cycles, and wherein the hemodynamic effects comprise contractility, aortic compliance, stroke volume, vascular tone, afterload, and full cardiac cycle. ### Claim 5 (depends on 4) The hemodynamic monitor of claim 4, wherein the plurality of waveform signal measures comprises: a mean, a maximum, a minimum, a duration, an area, a standard deviation, derivatives, and/or morphological measures from each of the systolic rise phase, the systolic decay phase, and the diastolic phase from each of the individual cardiac cycles; and/or heart rate, respiratory rate, stroke volume, pulse pressure, pulse pressure variation, stroke volume variation, mean arterial pressure (MAP), systolic pressure (SYS), diastolic pressure (DIA), heart rate variability, cardiac output, peripheral resistance, vascular compliance, and/or left-ventricular contractility extracted from each of the individual cardiac cycles. ### Claim 6 (depends on 5) The hemodynamic monitor of claim 5, wherein computing the combinatorial measures between the plurality of waveform signal measures of the first clinical dataset, the second clinical dataset, the third clinical dataset, and the fourth clinical dataset comprises: performing step one by arbitrarily selecting a subset of signal measures from the plurality of waveform signal measures; performing step two by calculating different orders of power for each signal measure of the subset of signal measures to generate powers of the subset of signal measures; performing step three by multiplying the powers of the signal measures of the subset of signal measures together to generate the product of the powers of the subset of signal measures; performing step four by performing receiver operating characteristic (ROC) analysis of the product to arrive at a combinatorial measure for the subset of signal measures; and repeating steps one, two, three, and four until all of the combinatorial measures have been computed between all of the plurality of waveform signal measures. ### Claim 7 (depends on 6) The hemodynamic monitor of claim 6, wherein the input features comprise a first subset and a second subset, and wherein the instructions, when executed by the system processor, are further configured to: extract the first subset and the second subset of the input features concurrently from the plurality of signal measures; concurrently determine a normal aortic stenosis score of the patient from the first subset of the input features and a severe aortic stenosis score of the patient from the second subset of the input features; and output the normal aortic stenosis and the severe aortic stenosis score of the patient to the display of the user interface. ### Claim 8 (depends on 7) The hemodynamic monitor of claim 7, wherein the input features comprise a third subset and a fourth subset, and wherein the instructions, when executed by the system processor, are further configured to: extract the first subset, the second subset, the third subset, and the fourth subset of the input features concurrently from the plurality of signal measures; concurrently determine the normal aortic stenosis score of the patient from the first subset of the input features, the severe aortic stenosis score of the patient from the second subset of the input features, a mild aortic stenosis score of the patient from the third subset of the input features, and a moderate aortic stenosis score of the patient from the fourth subset of the input features; output the normal aortic stenosis score of the patient, the mild aortic stenosis score of the patient, the moderate aortic stenosis score of the patient, and the severe aortic stenosis score of the patient to the display of the user interface. ### Claim 9 A method for triaging a patient for aortic stenosis, the method comprising: receiving, by a hemodynamic monitor, sensed hemodynamic data representative of an arterial pressure waveform of the patient; performing, by the hemodynamic monitor, waveform analysis of the sensed hemodynamic data to calculate a plurality of signal measures of the sensed hemodynamic data; extracting, by the hemodynamic monitor, input features from the plurality of signal measures that are indicative of an aortic stenosis score of the patient, wherein extracting the input features comprises: extracting a first subset of the input features; and extracting a second subset of the input features concurrently with the first subset of the input features; concurrently determining, by the hemodynamic monitor, a normal aortic stenosis score of the patient from the first subset of the input features and a severe aortic stenosis score of the patient from the second subset of the input features; and outputting the normal aortic stenosis score and the severe aortic stenosis score of the patient to a display and/or mobile device. ### Claim 10 (depends on 9) The method of claim 9, wherein extracting the input features further comprises: extracting a third subset of the input features concurrently with the first subset and the second subset of the input features; and extracting a fourth subset of the input features concurrently with the first subset, the second subset, and the third subset of the input features; and wherein the hemodynamic monitor concurrently determines the normal aortic stenosis score of the patient from the first subset of the input features, the severe aortic stenosis score of the patient from the second subset of the input features, a mild aortic stenosis score of the patient from the third subset of the input features, and a moderate aortic stenosis score of the patient from the fourth subset of the input features; and wherein the hemodynamic monitor outputs the normal aortic stenosis score of the patient, the mild aortic stenosis score of the patient, the moderate aortic stenosis score of the patient, and the severe aortic stenosis score of the patient to a display and/or mobile device. ### Claim 11 (depends on 10) The method of claim 10, further comprising alerting the patient and/or medical personnel that the aortic stenosis score is normal when the aortic stenosis score is within a first range; alerting the patient and/or the medical personnel that the aortic stenosis score is mild when the aortic stenosis score is within a second range; alerting the patient and/or the medical personnel that the aortic stenosis score is moderate when the aortic stenosis score is within a third range; and alerting the patient and/or the medical personnel that the aortic stenosis score is severe when the aortic stenosis score is within a fourth range. ### Claim 12 (depends on 11) The method of claim 11, further comprising: training the hemodynamic monitor for determining the aortic stenosis score of the patient, wherein training the hemodynamic monitor comprises: collecting a first clinical dataset containing arterial pressure waveforms from a first group of individuals with normal aortic valve function; labeling each of the arterial pressure waveforms of the first clinical dataset with a first label; performing waveform analysis of the labeled arterial pressure waveforms of the first clinical dataset to calculate a plurality of waveform signal measures of the first clinical dataset; determining the first subset of the input features by computing combinatorial measures between the plurality of waveform signal measures of the first clinical dataset and selecting top signal measures from the plurality of waveform signal measures of the first clinical dataset with most predictive combinatorial measures and labeling the top signal measures of the first clinical data set as the first subset of the input features; collecting a second clinical dataset containing arterial pressure waveforms from a second group of individuals with severe aortic stenosis, wherein severe aortic stenosis is defined as an aortic valve area less than 1 cm2; labeling each of the arterial pressure waveforms of the second clinical dataset with a second label; performing waveform analysis of the labeled arterial pressure waveforms of the second clinical dataset to calculate a plurality of waveform signal measures of the second clinical dataset; and determining a second subset of the input features by computing combinatorial measures between the plurality of waveform signal measures of the second clinical dataset and selecting top signal measures from the plurality of waveform signal measures of the second clinical dataset with most predictive combinatorial measures and labeling the top signal measures of the second clinical data set as the second subset of the input features. ### Claim 13 (depends on 12) The method of claim 12, wherein training the hemodynamic monitor for determining the aortic stenosis score of the patient further comprises: collecting a third clinical dataset containing arterial pressure waveforms from a third group of individuals with mild aortic stenosis, wherein mild aortic stenosis is defined as an aortic valve area greater than 1.5 cm2; labeling each of the arterial pressure waveforms of the third clinical dataset with a third label; performing waveform analysis of the labeled arterial pressure waveforms of the third clinical dataset to calculate a plurality of waveform signal measures of the third clinical dataset; determining a third subset of the input features by computing combinatorial measures between the plurality of waveform signal measures of the third clinical dataset and selecting top signal measures from the plurality of waveform signal measures of the third clinical dataset with most predictive combinatorial measures and labeling the top signal measures of the third clinical data set as the third subset of the input features; collecting a fourth clinical dataset containing arterial pressure waveforms from a fourth group of individuals with moderate aortic stenosis, wherein moderate aortic stenosis is defined as an aortic valve area between 1 cm2 and 1.5 cm2; labeling each of the arterial pressure waveforms of the fourth clinical dataset with a fourth label; performing waveform analysis of the labeled arterial pressure waveforms of the fourth clinical dataset to calculate a plurality of waveform signal measures of the fourth clinical dataset; and determining a fourth subset of the input features by computing combinatorial measures between the plurality of waveform signal measures of the fourth clinical dataset and selecting top signal measures from the plurality of waveform signal measures of the fourth clinical dataset with most predictive combinatorial measures and labeling the top signal measures of the fourth clinical data set as the fourth subset of the input features. ### Claim 14 (depends on 13) The method of claim 13, wherein: performing waveform analysis of the labeled arterial pressure waveforms of the first clinical dataset to calculate the plurality of waveform signal measures of the first clinical dataset comprises: identifying individual cardiac cycles in each of the arterial pressure waveforms of the first clinical dataset; identifying a dicrotic notch in each of the individual cardiac cycles in each of the arterial pressure waveforms of the first clinical dataset; identifying a systolic rise phase, a systolic decay phase, and a diastolic phase in each of the individual cardiac cycles in each of the arterial pressure waveforms of the first clinical dataset; and extracting the plurality of waveform signal measures of the first clinical dataset from each of the systolic rise phase, the systolic decay phase, and the diastolic phase from each of the individual cardiac cycles in each of the arterial pressure waveforms of the first clinical dataset; performing waveform analysis of the labeled arterial pressure waveforms of the second clinical dataset to calculate the plurality of waveform signal measures of the second clinical dataset comprises: identifying individual cardiac cycles in each of the arterial pressure waveforms of the second clinical dataset; identifying a dicrotic notch in each of the individual cardiac cycles in each of the arterial pressure waveforms of the second clinical dataset; identifying a systolic rise phase, a systolic decay phase, and a diastolic phase in each of the individual cardiac cycles in each of the arterial pressure waveforms of the second clinical dataset; and extracting the plurality of waveform signal measures of the second clinical dataset from each of the systolic rise phase, the systolic decay phase, and the diastolic phase from each of the individual cardiac cycles in each of the arterial pressure waveforms of the second clinical dataset; performing waveform analysis of the labeled arterial pressure waveforms of the third clinical dataset to calculate the plurality of waveform signal measures of the third clinical dataset comprises: identifying individual cardiac cycles in each of the arterial pressure waveforms of the third clinical dataset; identifying a dicrotic notch in each of the individual cardiac cycles in each of the arterial pressure waveforms of the third clinical dataset; identifying a systolic rise phase, a systolic decay phase, and a diastolic phase in each of the individual cardiac cycles in each of the arterial pressure waveforms of the third clinical dataset; and extracting the plurality of waveform signal measures of the third clinical dataset from each of the systolic rise phase, the systolic decay phase, and the diastolic phase from each of the individual cardiac cycles in each of the arterial pressure waveforms of the third clinical dataset; and performing waveform analysis of the labeled arterial pressure waveforms of the fourth clinical dataset to calculate the plurality of waveform signal measures of the fourth clinical dataset comprises: identifying individual cardiac cycles in each of the arterial pressure waveforms of the fourth clinical dataset; identifying a dicrotic notch in each of the individual cardiac cycles in each of the arterial pressure waveforms of the fourth clinical dataset; identifying a systolic rise phase, a systolic decay phase, and a diastolic phase in each of the individual cardiac cycles in each of the arterial pressure waveforms of the fourth clinical dataset; and extracting the plurality of waveform signal measures of the fourth clinical dataset from each of the systolic rise phase, the systolic decay phase, and the diastolic phase from each of the individual cardiac cycles in each of the arterial pressure waveforms of the fourth clinical dataset. ### Claim 15 (depends on 14) The method of claim 14, wherein: the plurality of waveform signal measures of the first clinical dataset correspond to hemodynamic effects from each of the systolic rise phase, the systolic decay phase, and the diastolic phase from each of the individual cardiac cycles in each of the arterial pressure waveforms of the first clinical dataset, and wherein the hemodynamic effects comprise contractility, aortic compliance, stroke volume, vascular tone, afterload, and full cardiac cycle; the plurality of waveform signal measures of the second clinical dataset correspond to hemodynamic effects from each of the systolic rise phase, the systolic decay phase, and the diastolic phase from each of the individual cardiac cycles in each of the arterial pressure waveforms of the second clinical dataset, and wherein the hemodynamic effects comprise contractility, aortic compliance, stroke volume, vascular tone, afterload, and full cardiac cycle; the plurality of waveform signal measures of the third clinical dataset correspond to hemodynamic effects from each of the systolic rise phase, the systolic decay phase, and the diastolic phase from each of the individual cardiac cycles in each of the arterial pressure waveforms of the third clinical dataset, and wherein the hemodynamic effects comprise contractility, aortic compliance, stroke volume, vascular tone, afterload, and full cardiac cycle; and/or the plurality of waveform signal measures of the fourth clinical dataset correspond to hemodynamic effects from each of the systolic rise phase, the systolic decay phase, and the diastolic phase from each of the individual cardiac cycles in each of the arterial pressure waveforms of the fourth clinical dataset, and wherein the hemodynamic effects comprise contractility, aortic compliance, stroke volume, vascular tone, afterload, and full cardiac cycle. ### Claim 16 (depends on 15) The method of claim 15, wherein: the plurality of waveform signal measures of the first clinical dataset comprises a mean, a maximum, a minimum, a duration, an area, a standard deviation, derivatives, and/or morphological measures from each of the systolic rise phase, the systolic decay phase, and the diastolic phase from each of the individual cardiac cycles in each of the arterial pressure waveforms of the first clinical dataset; the plurality of waveform signal measures of the second clinical dataset comprises a mean, a maximum, a minimum, a duration, an area, a standard deviation, derivatives, and/or morphological measures from each of the systolic rise phase, the systolic decay phase, and the diastolic phase from each of the individual cardiac cycles in each of the arterial pressure waveforms of the second clinical dataset; the plurality of waveform signal measures of the third clinical dataset comprises a mean, a maximum, a minimum, a duration, an area, a standard deviation, derivatives, and/or morphological measures from each of the systolic rise phase, the systolic decay phase, and the diastolic phase from each of the individual cardiac cycles in each of the arterial pressure waveforms of the third clinical dataset; and/or the plurality of waveform signal measures of the fourth clinical dataset comprises a mean, a maximum, a minimum, a duration, an area, a standard deviation, derivatives, and/or morphological measures from each of the systolic rise phase, the systolic decay phase, and the diastolic phase from each of the individual cardiac cycles in each of the arterial pressure waveforms of the fourth clinical dataset. ### Claim 17 (depends on 16) The method of claim 16, wherein: the plurality of waveform signal measures of the first clinical dataset comprises heart rate, respiratory rate, stroke volume, pulse pressure, pulse pressure variation, stroke volume variation, mean arterial pressure (MAP), systolic pressure (SYS), diastolic pressure (DIA), heart rate variability, cardiac output, peripheral resistance, vascular compliance, and/or left-ventricular contractility extracted from each of the individual cardiac cycles in each of the arterial pressure waveforms of the first clinical dataset; the plurality of waveform signal measures of the second clinical dataset comprises heart rate, respiratory rate, stroke volume, pulse pressure, pulse pressure variation, stroke volume variation, mean arterial pressure (MAP), systolic pressure (SYS), diastolic pressure (DIA), heart rate variability, cardiac output, peripheral resistance, vascular compliance, and/or left-ventricular contractility extracted from each of the individual cardiac cycles in each of the arterial pressure waveforms of the second clinical dataset; the plurality of waveform signal measures of the third clinical dataset comprises heart rate, respiratory rate, stroke volume, pulse pressure, pulse pressure variation, stroke volume variation, mean arterial pressure (MAP), systolic pressure (SYS), diastolic pressure (DIA), heart rate variability, cardiac output, peripheral resistance, vascular compliance, and/or left-ventricular contractility extracted from each of the individual cardiac cycles in each of the arterial pressure waveforms of the third clinical dataset; and/or the plurality of waveform signal measures of the fourth clinical dataset comprises heart rate, respiratory rate, stroke volume, pulse pressure, pulse pressure variation, stroke volume variation, mean arterial pressure (MAP), systolic pressure (SYS), diastolic pressure (DIA), heart rate variability, cardiac output, peripheral resistance, vascular compliance, and/or left-ventricular contractility extracted from each of the individual cardiac cycles in each of the arterial pressure waveforms of the fourth clinical dataset. ### Claim 18 (depends on 17) The method of claim 17, wherein computing the combinatorial measures between the plurality of waveform signal measures of the first clinical dataset comprises: performing step one by arbitrarily selecting a subset of signal measures from the plurality of waveform signal measures of the first clinical dataset; performing step two by calculating different orders of power for each signal measure of the subset of signal measures from the plurality of waveform signal measures of the first clinical dataset to generate powers of the subset of signal measures from the plurality of waveform signal measures of the first clinical dataset; performing step three by multiplying the powers of the subset of signal measures from the plurality of waveform signal measures of the first clinical dataset together to generate a product of the powers of the subset of signal measures from the plurality of waveform signal measures of the first clinical dataset; performing step four by performing receiver operating characteristic (ROC) analysis of the product of the powers of the subset of signal measures from the plurality of waveform signal measures of the first clinical dataset to arrive at a combinatorial measure for the product of the powers of the subset of signal measures from the plurality of waveform signal measures of the first clinical dataset; and repeating steps one, two, three, and four until all of the combinatorial measures have been computed between all of the plurality of waveform signal measures of the first clinical dataset. ### Claim 19 (depends on 18) The method of claim 18, wherein computing the combinatorial measures between the plurality of waveform signal measures of the second clinical dataset comprises: performing step one by arbitrarily selecting a subset of signal measures from the plurality of waveform signal measures of the second clinical dataset; performing step two by calculating different orders of power for each of the signal measures of the subset of signal measures from the plurality of waveform signal measures of the second clinical dataset to generate powers of the subset of signal measures from the plurality of waveform signal measures of the second clinical dataset; performing step three by multiplying the powers of the subset of signal measures from the plurality of waveform signal measures of the second clinical dataset together to generate a product of the powers of the subset of signal measures from the plurality of waveform signal measures of the second clinical dataset; performing step four by performing receiver operating characteristic (ROC) analysis of the product of the powers of the subset of signal measures from the plurality of waveform signal measures of the second clinical dataset to arrive at a combinatorial measure for the product of the powers of the subset of signal measures from the plurality of waveform signal measures of the second clinical dataset; and repeating steps one, two, three, and four until all of the combinatorial measures have been computed between all of the plurality of waveform signal measures of the second clinical dataset. ### Claim 20 (depends on 19) The method of claim 19, wherein computing the combinatorial measures between the plurality of waveform signal measures of the third clinical dataset comprises: performing step one by arbitrarily selecting a subset of signal measures from the plurality of waveform signal measures of the third clinical dataset; performing step two by calculating different orders of power for each of the signal measures of the subset of signal measures from the plurality of waveform signal measures of the third clinical dataset to generate powers of the subset of signal measures from the plurality of waveform signal measures of the third clinical dataset; performing step three by multiplying the powers of the subset of signal measures from the plurality of waveform signal measures of the third clinical dataset together to generate a product of the powers of the subset of signal measures from the plurality of waveform signal measures of the third clinical dataset; performing step four by performing receiver operating characteristic (ROC) analysis of the product of the powers of the subset of signal measures from the plurality of waveform signal measures of the third clinical dataset to arrive at a combinatorial measure for the product of the powers of the subset of signal measures from the plurality of waveform signal measures of the third clinical dataset; and repeating steps one, two, three, and four until all of the combinatorial measures have been computed between all of the plurality of waveform signal measures of the third clinical dataset; and wherein computing the combinatorial measures between the plurality of waveform signal measures of the fourth clinical dataset: performing step one by arbitrarily selecting a subset of signal measures from the plurality of waveform signal measures of the fourth clinical dataset; performing step two by calculating different orders of power for each of the signal measures of the subset of signal measures from the plurality of waveform signal measures of the fourth clinical dataset to generate powers of the subset of signal measures from the plurality of waveform signal measures of the fourth clinical dataset; performing step three by multiplying the powers of the subset of signal measures from the plurality of waveform signal measures of the fourth clinical dataset together to generate a product of the powers of the subset of signal measures from the plurality of waveform signal measures of the fourth clinical dataset; performing step four by performing receiver operating characteristic (ROC) analysis of the product of the powers of the subset of signal measures from the plurality of waveform signal measures of the fourth clinical dataset to arrive at a combinatorial measure for the product of the powers of the subset of signal measures from the plurality of waveform signal measures of the fourth clinical dataset; and repeating steps one, two, three, and four until all of the combinatorial measures have been computed between all of the plurality of waveform signal measures of the fourth clinical dataset.