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AssigneeThe Regents of the University of Colorado, a body corporate
InventorsBenjamin G. Bitler, Lindsay J. Wheeler
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Disclosed herein are method and compounds useful in the analysis, diagnosis, and treatment of high grade serous ovarian carcinoma (HGSOC). Also disclosed are methods, compounds, and compositions useful in regulating Chromobox 2 (CBX2) expression and therapies for stemness, anoikis escape, HGSOC dissemination, and HGSOC chemoresistance. Applicants have identified CBX2 expression as being significantly elevated in HGSOC cells and tissues compared to benign counterparts. Also disclosed is elevated CBX2 expression in HGSOC cell lines, as well as elevated CBX2 expression in cells that are forced to grown in suspension. CBX2 expression can be used to identify subjects for treatment with therapies specifically directed to cancers characterized by CBX2 upregulation.
A method of classifying a tumor for treatment, comprising:
A method of determining a treatment for a patient with an ovarian cancer, the method comprising:
A kit for classifying a tumor for treatment, comprising an article providing a scale of immunohistochemistry scores, and that indicates a minimum score that identifies a sample having that score as coming from a tumor that is likely responsive to a treatment with an Aurora kinase inhibitor.
Dependencies are inferred from the claim text.