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AssigneeAXR Pharma Inc.
InventorsChing-Fen Wu, Yun-Lian Lin, Yi-Yueh Wang, Hung-Chih Kuo, Kun-Wei Chan
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The present invention provides a method for diagnosing pancreatitis in a canine. The method involves the following steps: First, a specimen is obtained from a canine animal. Then, a concentration of a specific biomarker in the specimen is detected, and the detected concentration is compared with a predetermined threshold value. If the biomarker concentration exceeds the threshold, the canine is determined to have an increased risk of pancreatitis. The predetermined threshold is based on the biomarker concentration observed in healthy canine animals. The biomarker can include medium-chain acylcarnitine, long-chain acylcarnitine, or a combination of both. Medium-chain acylcarnitine refers to those molecules with 6-12 carbon atoms in the acyl chain. Long-chain acylcarnitine refers to those molecules with more than 12 carbon atoms in the acyl chain. Additionally, the invention provides a method for using acylcarnitines (medium-chain and/or long-chain) as biomarkers for diagnosing pancreatitis in canines.
A method for diagnosing pancreatitis in a canine, comprising:
A diagnostic kit for pancreatitis in canine animals, comprising a detection reagent, wherein said detection reagent, when mixed with a specimen obtained from a canine animal, a concentration of a biomarker in the specimen can be detected, wherein the biomarker refers to medium-chain acylcarnitine, long-chain acylcarnitine, or a combination thereof, and the medium-chain refers to acylcarnitines with a chain length of 6 to 12 carbon atoms, and long-chain refers to acylcarnitines with a chain length of more than 12 carbon atoms.
A method of utilizing medium-chain acylcarnitine, long-chain acylcarnitine, or a combination thereof for diagnosing pancreatitis in a canine, wherein medium-chain refers to acylcarnitines with a chain length of 6 to 12 carbon atoms, and long-chain refers to those with a chain length of more than 12 carbon atoms.
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