Compositions and methods for treating and preventing hepatitis b and d
AssigneeSVF Vaccines AB
InventorsMatti Sällberg, Lars Frelin, Nico Mertens
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Abstract
Disclosed herein are immunogenic compositions or product combinations of engineered hepatitis B and hepatitis D nucleic acids, genes, peptides, or proteins that can be used to elicit an immune response against a hepatitis B and/or hepatitis D infection. Also disclosed are methods of using the immunogenic compositions or product combinations in subjects to generate immune responses against HBV and/or HDV by administering the compositions or combinations, for example, with a nucleic acid prime and polypeptide boost approach.
Claims24
A polypeptide comprising at least one hepatitis D antigen (HDAg) polypeptide sequence and at least one PreS1 polypeptide sequence, wherein each of the at least one HDAg polypeptide sequence is a C211S mutant HDAg polypeptide sequence.
2-56. (canceled)
A nucleic acid operon comprising two or more genes, wherein each of the two or more genes comprise at least one HDAg nucleic acid sequence and at least one PreS1 nucleic acid sequence, and wherein each of the two or more genes comprises a 5′ ribosome binding site, wherein the at least one HDAg nucleic acid sequence encodes a polypeptide comprising a C211 mutation.
Dependencies are inferred from the claim text.