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US 2025/0197413 A1Published application
Rxfp1 receptor agonists
AssigneeEli Lilly and Company
InventorsErin ANDERSON, Todd FIELDS, Autumn Rose FLYNN, Megan MCKENNEY HALL, Richard Duane JOHNSTON, Jason Eric LAMAR, Christopher MAYNE, Elizabeth MCFADDIN, Andrew METCALF, Tarek SAMMAKIA, Zhicheng SUN
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Abstract
The present invention provides compounds of the formula: wherein Ring A, R1, R2, and R3 are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and pharmaceutically acceptable salts thereof for treating patients for cardiovascular, pulmonary and/or renal conditions, diseases and/or disorders.
Claims26
A compound of the formula:
- wherein:
- Ring A is a group of the formula
- wherein each of
- is optionally substituted by one or more substituents selected from halogens, —CN, C1-4 alkyl, —S—C1-3 alkyl, and C1-3 alkoxy, wherein each C1-4 alkyl and C1-3 alkoxy is independently optionally substituted by one or more substituents selected from halogens and —CN;
- —Y— is a C1-3 alkylene;
- —G6— is —C(R1)— or —N—;
- R1 is C1-3 alkoxy;
- R2 is —OCH2COOH or an N-linked 4-7 membered heterocycle;
- wherein the N-linked 4-7 membered heterocycle is selected from an azetidine, pyrrolidine, morpholine, piperazine, piperidine, and oxazepane;
- wherein the heterocycle is optionally bridged by, fused with, or spiro-linked with a C1-4 alkylenyl, or a 1-5 membered heteroalkyl;
- wherein the heterocycle, the C1-4 alkylenyl, and the 1-5 membered heteroalkyl are each optionally substituted with 1-3 substituents each independently selected from halogen, oxo, C1-4 alkyl, C1-4 haloalkyl, —OH, and —COOH;
- R3 is selected from the group consisting of
- wherein
- is optionally substituted with one to three halogens;
- —G4— is —CH— or —N—;
- —G5— is —CH2— or —O—;
- R3a, at each occurrence, is independently —H, halogen, —SF5, —SO2CF3, —SCF3, —CN, C1-4 alkyl, C3-6 cycloalkyl, or C1-3 alkoxy, wherein the C1-4 alkyl and C1-3 alkoxy are optionally substituted with one, two or three halogens;
- R3b is independently —H, halogen, difluoromethyl, trifluoromethyl, methoxy, trifluoromethoxy, —CN, or C1-4 alkyl;
- R3c, at each occurrence, is independently —H or halogen;
- R3d is —H, halogen, —CN, C1-4 alkyl, C3-6 cycloalkyl, or C1-3 alkoxy, wherein the C1-4 alkyl and C1-3 alkoxy are optionally substituted with one, two, or three halogens;
- or a pharmaceutically acceptable salt thereof.
18 more elements
Dependencies are inferred from the claim text.