Substituted derivatives of isoindoles
AssigneeSupernus Pharmaceuticals, Inc.
InventorsGary L. Olson, Bhaskara Rao Nallaganchu, Yanjun Sun
Life of this patent
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Abstract
Substituted derivatives of 5-(4-chlorophenyl)-2,3-dihydroimidazo[1,2-b]isoindol-5-ol and their uses in pharmaceutical compositions for the treatment of central nervous system diseases or disorders are provided.
Claims19
An isoindoline derivative of Formula I, or a stereoisomer or a pharmaceutically acceptable salt thereof:
- wherein:
- R1 is an alkyl group, an alkenyl group, an aralkyl group, an alkoxyalkyl group, a carboxyalkyl ester group, a cinnamyl group, a heteroalkyl group or a heterocycloalkyl group;
- and
- R2-R5 are each independently H or alkyl;
- and
- R6-R14 are each independently H, alkyl, alkoxy, F, Cl, Br, CF3 or I,
- wherein the isoindoline derivative is not of formula I-6:
A method for treating a central nervous system disorder in a mammal, the method comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula I, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof:
- wherein R1 is an alkyl group, an alkenyl group, an aralkyl group, an alkoxyalkyl group, a carboxyalkyl ester group, a cinnamyl group, a heteroalkyl group or a heterocycloalkyl group;
- R2-R5 are each independently H or alkyl;
- and R6-R14 are each independently H, alkyl, alkoxy, F, Cl, Br, CF3 or I.
A method of making an isoindoline derivative of Formula I comprising contacting Compound A (5-(4-chlorophenyl)-2,3-dihydroimidazo[1,2-b]isoindol-5-ol) or a pharmaceutically acceptable salt thereof, with a reactive compound suitable for forming the derivative of Formula I,
- wherein R1 is an alkyl group, an alkenyl group, an aralkyl group, an alkoxyalkyl group, a carboxyalkyl ester group, a cinnamyl group, a heteroalkyl group or a heterocycloalkyl group;
- R2-R5 are each independently H or alkyl;
- and R6-R14 are each independently H, alkyl, alkoxy, F, Cl, Br, CF3 or I.
Dependencies are inferred from the claim text.