Compounds, pharmaceutical compositions and methods for treating inflammatory bowel disease

A compound of Formula I:

• wherein:
• R1, R2, R3, and R4 are each, independently, H or optionally substituted C1-6alkyl;
• R5 is OH, optionally substituted C1-6alkoxy, —N(RA)(optionally substituted C1-6alkyl), or —X(RA)—R15—CH(X6)(X7)R11R12;
• R15 is —C1-6alk-;
• RA is H or optionally substituted C1-6alkyl;
• X is O or NH;
• X1 is CR6 or N;
• X2 is CR7 or N;
• X3 is CR8 or N;
• X4 is CR9 or N;
• X5 is CR10 or N;
• X6 and X7 are each, independently, H or optionally substituted C1-6alkyl, or both are N and join to form a diazirinyl ring;
• R6, R7, R8, R9, and R10 are each, independently, H, OH, halo, optionally substituted C1-6alkyl, optionally substituted C1-6alkoxy, or —(OC1-6alk)n-C1-6alkyl;
• R11 and R12 are each, independently, optionally substituted C1-6alkyl, optionally substituted C2-6alkenyl, optionally substituted C2-6alkynyl, optionally substituted C1-6alkoxy, OH, NH2, or N(R13)(R14);
• R13 and R14 are each, independently, H or C1-6alkyl;
• n is 2-8;
• and
• provided that only one of X1—X5 is N;
• or a pharmaceutically acceptable salt thereof.