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US 2025/0197383 A1Published application
Small molecule inhibitors of enpp1
AssigneeThe Regents of the University of California
InventorsArjun Deb, Michael E. Jung, Xiaohong Chen, Shen Li, Yanpeng Xing, Hui Ding
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Abstract
The present disclosure relates to compounds that are capable of inhibiting the ENPP1 gene and treating a variety of cardiac conditions. The disclosure further relates to methods of treating or preventing cardiac conditions, such as myocardial infarction and heart failure.
Claims32
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof;
- wherein:
- each R1 is independently heteroaryl;
- and
- R2 is selected from:
2 more elements
A compound is selected from
- or a pharmaceutically acceptable salt thereof,
- wherein R4 is selected from -alkylene-C(O)NHOH, -alkylene-C(O)NH-alkoxy, -cycloalkylene-C(O)NHOH, and -cycloalkylene-C(O)NH-alkoxy.
Dependencies are inferred from the claim text.