Pparg inverse agonists and uses thereof

A compound having the Formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• X, Y, and Z are each independently selected from N and —CR4;
• R1 is selected from phenyl, heterocyclyl, and heteroaryl, each of which are optionally substituted with 1 to 3 groups selected from R5;
• R2 is selected from halo, —SRa, —SORa, —SO2R, —OR, and —SO(═NRa)Rb;
• R3 is selected from cyano and nitro;
• R4 is selected from hydrogen, halo, (C1-C4)alkyl, halo(C1-C4)alkyl, (C1-C4)alkoxy, and hydroxyl;
• R5 is selected from halo, (C1-C4)alkyl, (C1-C4)alkoxy, halo(C1-C4)alkyl, halo(C1-C4)alkoxy, cyano, oxo, —(C1-C4)alkylORa, —(C1-C4)alkylC(O)Ra, —(C1-C4)alkylC(O)ORa, —C(O)NRaRb, —(C1-C4)alkylC(O)NRaRb, —C(O)Ra, —C(O)ORa, —NRaRb, —(C1-C4)alkylNRaRb, —C(O)NRaSO3H, —NRaC(O)Rb, —NRaC(O)ORb, —NRaC(S)ORb, —NRcC(O)NaRb, —NRcC(S)NRaRb, —NRS(O)2NRaRb, —C(S)Ra, —S(O)2Ra, —S(O)Ra, —C(S)ORa, —C(S)NRaRb, —NRaC(S)Rb, —SRa, —O(phenyl), phenyl, heterocyclyl, and heteroaryl, wherein each of said phenyl, heterocyclyl, heteroaryl, and the phenyl group on —O(phenyl) are optionally and independently substituted with 1 to 3 groups selected from R6;
• R6 is selected from halo, (C1-C4)alkyl, halo(C1-C4)alkyl, (C1-C4)alkoxy, halo(C1-C4)alkoxy, nitro, oxo, cyano, —(C1-C4)alkylORd, —(C1-C4)alkylC(O)Rd, —(C1-C4)alkylC(O)ORd, —C(O)NRdRe, —(C1-C4)alkylC(O)NRdRe, —C(O)Rd, —C(O)ORd, —NRdRe, —(C1-C4)alkylNRdRe, —C(O)NRdSO3H, —NRdC(O)Re, —NRdC(O)ORe, —NRdC(S)ORe, —NRfC(O)NdRe, —NRfC(S)NRdRe, —NRfS(O)2NRdRe, —C(S)Rd, —S(O)2Rd, —S(O)Rd, —C(S)ORd, —C(S)NRdRe, —NRdC(S)Re, and —SRd;
• and
• Ra, Rb, Rc, Rd, and Re are each independently selected from hydrogen, (C1-C4)alkyl, and halo(C1-C4)alkyl.