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US 2025/0197197 A1Published application
Integrated analysis devices and related fabrication methods and analysis techniques
AssigneeBionano Genomics, Inc.
InventorsHan Cao, Michael David Austin, Parikshit A. Deshpande, Mark Kunkel, Alexey Y. Sharonov, Michael Kochersperger
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Abstract
Provided are integrated analysis devices having features of macroscale and nanoscale dimensions, and devices that have reduced background signals and that reduce quenching of fluorophores disposed within the devices. Related methods of manufacturing these devices and of using these devices are also provided.
Claims21
-100. (canceled)
An analysis device comprising:
- two or more ports in fluid communication with the primary fluidic channel and the environment exterior to the analysis device;
- a primary fluidic channel having a width in the range of from about 10 nm to less than about 10000 nm;
- two or more additional fluidic channels in fluid communication with the primary fluidic channel and of successively decreasing width,
- wherein the ratio of the widths of the primary fluidic channel and each of the narrowest additional fluidic channels is in the range of from about 100 to about 10000,
- wherein the total widths of the narrowest additional fluidic channels are approximately equal to the width of the primary fluidic channel;
- and
- a nanochannel analysis region in the two or more additional fluidic channels, said nanochannel analysis region configured for detection of electromagnetic signals from therein,
- wherein a ratio of the cross-sectional dimensions of the primary channel to the nanochannel analysis region is in the range of from about 100 to about 10,000.
5 more elements
Dependencies are inferred from the claim text.