Analytical method and therapeutical agent for use in combination with l-asparaginase in tumour therapy
AssigneeMedizinische Hochschule Hannover
InventorsLaura Hinze, Nurul Khalida Ibrahim
Life of this patent
Estimating the term…
Abstract
The invention provides an analytical method for detecting the level of activity of superoxide dismutase (SOD2, e.g. UniProtKB P04179 (SODM_HUMAN) and/or of UBR1 and/or of UBR2 in a sample originating from a patient for determining the sensitivity for, or resistance against, tumour treatment with L-asparaginase.
Claims8
Method for analysis of sensitivity for, or resistance against, tumour treatment with L-asparaginase in a sample originating from a patient, characterized by analysing the activity level of UBR1 and/or of UBR2, and/or by analysing the activity of superoxide dismutase 2 (SOD2).
L-asparaginase for use in the treatment of a tumour, comprising a combination of L-asparaginase with an inhibitor of SOD2 and/or an inhibitor of UBR2 and/or an inhibitor of UBR1, for use in the treatment of a tumour.
Dependencies are inferred from the claim text.