Morreton viruses and methods of use
AssigneeMayo Foundation for Medical Education and Research
InventorsMitesh J. BORAD, Bolni M. NAGALO
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Abstract
This document relates to methods and materials for treating cancer. For example, Morreton viruses (MORVs; e.g., recombinant MORVs) and methods for using such MORVs as an oncolytic agent (e.g., to treat cancer) are provided.
Claims28
A recombinant Morreton virus (MORV), wherein the genome of said MORV comprises:
- (a) a leader sequence of a first Vesiculovirus species different from said MORV;
- (b) a synthetic intergenic region;
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- (c) a trailer sequence of a second Vesiculovirus species different from said MORV.
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A method for treating a mammal having cancer, wherein said method comprises administering, to said mammal, a composition comprising MORV, wherein the number of cancer cells within said mammal is reduced.
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Dependencies are inferred from the claim text.