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US 2025/0195449 A1Published application
Melt processed viral nanoparticle constructs
AssigneeCase Western Reserve University
InventorsNicole F. Steinmetz, Jonathan Pokorski
Life of this patent
Estimating the term…
Abstract
A melt processed viral nanoparticle construct for delivery of virus or virus-like particles to a site of interest includes a degradable polymer matrix and a plurality of virus or virus-like particles encapsulated within the degradable polymer matrix. The nanoparticle construct upon administration to the site of interest providing a sustained release of the virus or virus-like particles and/or nanoparticles upon degradation of the polymer matrix.
Claims15
1-43. (canceled)
A method of treating cancer or tumor in a subject in need thereof, the method comprising:
- administering in situ to cancer or tumor cells of the subject a melt processed nanoparticle construct, the nanoparticle construct comprising:
- a biodegradable polymer matrix;
- and
- a plurality of virus or virus-like particles encapsulated with the biodegradable polymer matrix, the nanoparticle construct upon in situ delivery to the subject providing a sustained release of the virus or virus-like particles to the cancer or tumor cells, the virus or virus-like particles upon release from the biodegradable polymer matrix having the same or substantially similar structural and/or biochemical characteristics as the virus or virus-like particles prior to melt processing.
1 more element
57-75. (canceled)
Dependencies are inferred from the claim text.