Continuous spin freeze-drying of nucleic acid containing compositions

A method for freeze-drying a nucleic acid containing composition, the method comprising the steps of:

• a) loading a container having an inner and an outerwall with a nucleic acid containing liquid formulation comprising above 15% (w/v) of cryoprotectant;
• b) spinning said container of step a) along an axis, thereby allowing said formulation to form a layer at the circumferential inner wall of said container;
• c) while continuing spinning said container of step b), cooling said container to freeze-dry said formulation at the circumferential inner wall;
• thereby obtaining a spin-frozen container;
• d) drying said spin-frozen container of step c) by subjecting said container to a heating source which provides a homogenous heat transfer to the circumferential inner wall of the container, to form a dried nucleic acid containing composition.