Probe and method for sensing cellular signals
AssigneeSamsung Electronics Co., Ltd.
InventorsMikyung KIM, Kitae PARK, Carlos Cristiano DE JESUS ALCANTARA, Jonghan KIM, Chisung BAE, Anes JU
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Abstract
A probe apparatus for sensing a cellular signal includes a base layer, an extracellular electrode disposed on the base layer, a first middle layer that is disposed on the base layer and configured to cover the extracellular electrode, an intracellular electrode that is disposed on the first middle layer, a second middle layer that is disposed on the first middle layer and configured to cover the intracellular electrode, a cover layer disposed on the second middle layer, and a fluid-flow channel provided between the second middle layer and the cover layer.
Claims20
A probe apparatus for sensing cellular signals, the apparatus comprising:
- a base layer;
- a first electrode disposed on the base layer and comprising a first electrode head, a first electrode line extending from the first electrode head, and a first electrode terminal extending from the extracellular electrode line;
- a first middle layer that is disposed on the base layer and is configured to cover the first electrode line;
- a second electrode that is disposed on the first middle layer and provided spaced apart from the first electrode, wherein the second electrode comprises a second electrode head, a second electrode line formed extending from the second electrode head, and a second electrode terminal extending from the second electrode line;
- a second middle layer that is disposed on the first middle layer and is configured to cover the second electrode line;
- a cover layer disposed on the second middle layer;
- and
- a fluid-flow channel provided between the second middle layer and the cover layer.
A probe apparatus for sensing a cellular signal, the apparatus comprising:
- a base layer;
- a second electrode disposed on the base layer;
- a first middle layer that is disposed on the base layer and configured to cover at least a portion of the second electrode;
- a first electrode disposed on the first middle layer and provided spaced apart from the second electrode;
- a second middle layer that is disposed on the first middle layer and configured to cover at least a portion of the first electrode;
- a sacrificial layer disposed on the second middle layer and provided spaced apart from the second electrode and the first electrode, the sacrificial layer comprising a material that dissolves in a liquid;
- and
- a cover layer disposed on the sacrificial layer.
A cell probe comprising:
- a pointed shaft and a body together comprising a first sensing set;
- the pointed shaft including a first opening at a pointed end of the shaft;
- the first sensing set comprising a first fluid pathway, a first electrical pathway, and a second electrical pathway;
- the first fluid pathway comprising a first tunnel passing longitudinally through the shaft and having one end opening at the first hole;
- the first electrical pathway comprising a first electrode pad exposed via the first hole and a first electrical line connected to the first electrode pad;
- and
- the second electrical pathway comprising a second electrode pad exposed via the first hole and a second electrical line connected to the second electrode pad.
Dependencies are inferred from the claim text.