Anti-complement c1s antibodies and uses thereof
AssigneeBioverativ USA Inc.
InventorsPeter Van Vlasselaer, Graham Parry, Nancy E. Stagliano, Sandip Panicker
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Abstract
The present disclosure provides antibodies that bind complement C1s protein; and nucleic acid molecules that encode such antibodies. The present disclosure also provides compositions comprising such antibodies, and methods to produce and use such antibodies, nucleic acid molecules, and compositions.
Claims80
An antibody that binds a complement C1s protein, wherein the antibody comprises a complementarity-determining region (CDR) having an amino acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, and SEQ ID NO:6.
An antibody that binds a complement C1s protein, wherein the antibody specifically binds an epitope within the complement C1s protein, wherein the antibody competes for binding the epitope with an antibody that comprises light chain CDRs of an antibody light chain variable region comprising amino acid sequence SEQ ID NO:7 and heavy chain CDRs of an antibody heavy chain variable region comprising amino acid sequence SEQ ID NO:8.
An antibody that competes for binding the epitope bound by antibody IPN003.
An antibody comprising a variable domain of antibody IPN003.
Antibody IPN003.
Dependencies are inferred from the claim text.