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US 2025/0188019 A1Published application
Compounds and methods for liquid phase synthesis
AssigneeEli Lilly and Company
InventorsMichael Eugene KOPACH, John LEE, Emily Suzanne MURZINSKI, Vineeta RUSTAGI, Heba Azmy Fahim Ibrahim SALIM
Life of this patent
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Abstract
The present disclosure comprises hydrophilic linker compounds of Formula 1: and describes methods for their use in liquid phase synthesis. In Formula 1, “m” is 0 to 20, “n” is 1 to 50, and “Z” is a linker compound as described herein.
Claims24
A compound of the formula
- wherein “m” is 0 to 20, “n” is 1 to 50, and “Z” is a linker compound.
-7. (canceled)
-10. (canceled)
A peptide of SEQ ID NO:
- 1, 3, 5, 6, 8, 9, 11, 12, 14, 15, 16, 17, 18, 19, 20, 21, 22 or 23.
A method of preparation of the peptide of:
- a) SEQ ID NO:
- 2, comprising preparing the peptide of SEQ ID NO:
- 1 using liquid-phase peptide synthesis, and then treating the prepared peptide of SEQ ID NO:
- 1 with an acid to give the peptide of SEQ ID NO:
- 2;
- b) SEQ ID NO:
- 4, comprising preparing the peptide of SEQ ID NO:
- 3 using liquid-phase peptide synthesis, and then treating the prepared peptide of SEQ ID NO:
- 3 with an acid to give the peptide of SEQ ID NO:
- 4;
- c) SEQ ID NO:
- 7, comprising preparing the peptide of SEQ ID NO:
- 6 using liquid-phase peptide synthesis, and then treating the prepared peptide of SEQ ID NO:
- 6 with an acid to give the peptide of SEQ ID NO:
- 7;
- d) SEQ ID NO:
- 10, comprising preparing the peptide of SEQ ID NO:
- 9 using liquid-phase peptide synthesis, and then treating the prepared peptide of SEQ ID NO:
- 9 with an acid to give the peptide of SEQ ID NO:
- 10;
- e) SEQ ID NO:
- 13, comprising preparing the peptide of SEQ ID NO:
- 11, 12, 14, 15, 16, 17, or 18 using liquid-phase peptide synthesis, and then treating the prepared peptide of SEQ ID NO:
- 11, 12, 14, 15, 16, 17, or 18 with an acid to give the peptide of SEQ ID NO:
- 13;
- f) SEQ ID NO:
- 20, comprising coupling the peptide of SEQ ID NO:
- 19 with the peptide of SEQ ID NO:
- 7;
- or
- g) SEQ ID NO:
- 22, comprising coupling the peptide of SEQ ID NO:
- 21 with the peptide of SEQ ID NO:
- 10.
31 more elements
-37. (canceled)
The compound which is
-44. (canceled)
-47. (canceled)
Dependencies are inferred from the claim text.