Globular nanostructures

A plurality of globular nanostructures having an average hydrodynamic diameter between 20 to 50 nm, wherein each nanostructure is a polymeric nanostructure comprising:

• a central part comprising monomer residues according to Formula (I):
• wherein
• each R1, R2, R3, R4, R5, and R6 is independently chosen from the group consisting of H, a negative charge, and a covalent bond;
• each R7, R8, R9, and R10 is independently chosen from the group consisting of H, a negative charge, and lower alkyls, wherein at least 95% of all of the R7, R8, R9, and R10 groups are H or a negative charge;
• n is an integer between 2 and 5;
• and
• m is an integer between 2 and 5;
• an anchoring layer surrounding the central part, wherein the anchoring layer comprises monomer residues according to Formula (II):
• wherein
• each R11, R12, R13, R14, R15, and R16 is independently chosen from the group consisting of H, a negative charge, and a covalent bond;
• and
• p is 1 or 2;
• and
• a coating layer surrounding the anchoring layer, wherein the coating layer comprises monomer residues according to Formula (III):
• wherein
• each R17, R18, R19, R20, R21, and R22 is independently chosen from the group consisting of H, a negative charge, and a covalent bond;
• q is an integer between 2 and 5;
• r is an integer between 2 and 5;
• each R23 and R24 is independently chosen from the group consisting of H and lower alkyls;
• s is an integer between 30 and 105;
• and
• t is an integer between 30 and 105.